Journal article
Expression of TTF-1 in breast cancer independently of ER expression: A case report and pathogenic implications
Breast disease, Vol.37(1), pp.1-6
2017
DOI: 10.3233/BD-160240
PMID: 27983521
Abstract
Thyroid Transcription Factor 1 (TTF-1) is often used for the immunohistochemical evaluation of lung cancers, as a significant proportion of these cancers are positive while other adenocarcinomas are usually negative. Breast cancers are known to express TTF-1 only in a small minority of cases but this may be problematic when this staining is used for its differential diagnosis from lung cancer. We present a case of ER-positive breast cancer in 30% of tumor cells that was also TTF-1 positive in some areas of the primary tumor but lost ER expression completely in the metastatic recurrence site while retaining TTF-1 positivity. Additionally, a PTEN mutation was present on genomic evaluation of the primary tumor. Diagnostic, pathogenic and therapeutic implications of these findings are discussed.
Details
- Title: Subtitle
- Expression of TTF-1 in breast cancer independently of ER expression: A case report and pathogenic implications
- Creators
- Ioannis A Voutsadakis - NOSM UniversityPaul Mozarowski - Sault Area Hospital
- Resource Type
- Journal article
- Publication Details
- Breast disease, Vol.37(1), pp.1-6
- DOI
- 10.3233/BD-160240
- PMID
- 27983521
- ISSN
- 0888-6008
- eISSN
- 1558-1551
- Language
- English
- Date published
- 2017
- Academic Unit
- Internal Medicine
- Record Identifier
- 9984806503902771
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