Journal article
Expression of beta-Catenin in Human Tooth Germ
Analytical and quantitative cytology and histology, Vol.31(5), pp.324-331
10/01/2009
PMID: 20701100
Abstract
OBJECTIVE: To evaluate beta-catenin expression in human tooth germ development.
STUDY DESIGN: Specimens of 7 human fetuses aged between the ninth and sixteenth week were examined for beta-catenin expression by immunohistochemistry.
RESULTS: In the bud stage, we observed catenin membranous positivity for all primitive dental lamina and dental ridge cells, cytoplasmic positivity for tooth bud and intense nuclear positivity for early-condensed dental mesenchyme. The cap stage was marked by intense cytoplasmic and nuclear positivity in the outer and inner enamel epithelium and the dental papilla and by moderate cytoplasmic positivity in the enamel knot. In the early bell stage, we noted strong cytoplasmic and nuclear staining in the inner and outer enamel epithelium, only moderate membranous and cytoplasmic staining in the stellate reticulum, a high percentage of intense nuclear positivity in the dental papilla and strong focal nuclear and cytoplasmic positivity in the dental sac.
CONCLUSION: All areas with close contact between epithelial structures and ectomesenchymal cells showed increased expression of delocalized cytoplasmic and nuclear beta-catenin. Nuclear localization, tissue expression pattern and timing suggest a pivotal role for beta-catenin in the transcriptional activation of genes probably involved in the mesenchyme-epithelial interactions on which human tooth development is based. (Anal Quant Cytol Histol 2009;31:324-331)
Details
- Title: Subtitle
- Expression of beta-Catenin in Human Tooth Germ
- Creators
- Lorenzo Lo Muzio - University of FoggiaLucio Lo Russo - University of FoggiaGiuseppe Pannone - University of FoggiaAngela Santoro - University of FoggiaRosalia Leonardi - University of CataniaRosario Serpico - University of Naples Federico IIAlberto Gasparoni - University of SienaPantaleo Bufo - University of Foggia
- Resource Type
- Journal article
- Publication Details
- Analytical and quantitative cytology and histology, Vol.31(5), pp.324-331
- PMID
- 20701100
- NLM abbreviation
- Anal Quant Cytol Histol
- ISSN
- 0884-6812
- eISSN
- 2690-7593
- Publisher
- Sci Printers & Publ Inc
- Number of pages
- 8
- Language
- English
- Date published
- 10/01/2009
- Academic Unit
- Oral Pathology, Radiology and Medicine; Dental Clinic Administration
- Record Identifier
- 9984367630902771
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