Expression of cadherin 17 in well-differentiated neuroendocrine tumours

Anthony N Snow; Shamlal Mangray; Shaolei Lu; Rashna Clubwala; Jianhong Li; Murray B Resnick; Evgeny Yakirevich

doi:10.1111/his.12610

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Expression of cadherin 17 in well-differentiated neuroendocrine tumours

Journal article

Peer reviewed

Expression of cadherin 17 in well-differentiated neuroendocrine tumours

Anthony N Snow, Shamlal Mangray, Shaolei Lu, Rashna Clubwala, Jianhong Li, Murray B Resnick and Evgeny Yakirevich

Histopathology, Vol.66(7), pp.1010-1021

06/2015

DOI: 10.1111/his.12610

PMID: 25388236

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Abstract

Cadherin 17 (CDH17) is expressed primarily in normal intestinal epithelium and digestive tract tumours, and has limited expression in other neoplasms. The aims of this study were to examine CDH17 expression in well-differentiated neuroendocrine tumours (WDNETs) from various primary sites, representing the foregut, midgut, and hindgut, and tumours metastasizing to the liver, and to correlate the differences between the expression of CDH17, CDX2, and thyroid transcription factor 1 (TTF1). We investigated CDH17 immunohistochemical expression in 150 primary WDNETs from eight anatomical sites, including 68 from the foregut, 70 from the midgut, and 12 from the hindgut, and 15 metastases. CDH17 immunoreactivity increased significantly from foregut to hindgut WDNETs (P < 0.0001). Pancreatic WDNETs expressed CDH17 at a significantly higher frequency than other foregut tumours. Within the midgut, appendiceal and small-intestinal WDNETs were more frequently positive for CDH17 than for CDX2. All hindgut WDNETs expressed CDH17, in contrast to CDX2 (positive in one rectal case). CDH17 expression in liver metastases was similar to that of the primary tumours. This study is the first to comprehensively examine CDH17 expression in WDNETs from different sites. CDH17 is a sensitive marker for midgut WDNETs, and the CDH17+/CDX2-/TTF1- phenotype was found to be sensitive (92%) and specific (91%) for hindgut WDNETs.

DNA-Binding Proteins - metabolism

Immunohistochemistry

Neuroendocrine Tumors - pathology

Cadherins - metabolism

Neuroendocrine Tumors - metabolism

Humans

Intestinal Neoplasms - metabolism

Biomarkers, Tumor - metabolism

Male

Transcription Factors

Intestinal Neoplasms - pathology

Details

Title: Subtitle: Expression of cadherin 17 in well-differentiated neuroendocrine tumours
Creators: Anthony N Snow - Department of Pathology, University of Iowa Hospitals and Clinics, Iowa City, IA, USA
Shamlal Mangray - Department of Pathology, Rhode Island Hospital and Alpert Medical School of Brown University, Providence, RI, USA
Shaolei Lu - Department of Pathology, Rhode Island Hospital and Alpert Medical School of Brown University, Providence, RI, USA
Rashna Clubwala - Department of Pathology, Rhode Island Hospital and Alpert Medical School of Brown University, Providence, RI, USA
Jianhong Li - Department of Pathology, Rhode Island Hospital and Alpert Medical School of Brown University, Providence, RI, USA
Murray B Resnick - Department of Pathology, Rhode Island Hospital and Alpert Medical School of Brown University, Providence, RI, USA
Evgeny Yakirevich - Department of Pathology, Rhode Island Hospital and Alpert Medical School of Brown University, Providence, RI, USA
Resource Type: Journal article
Publication Details: Histopathology, Vol.66(7), pp.1010-1021
Publisher: England
DOI: 10.1111/his.12610
PMID: 25388236
ISSN: 0309-0167
eISSN: 1365-2559
Grant note: P20GM103421 / NIGMS NIH HHS
Language: English
Date published: 06/2015
Academic Unit: Pathology
Record Identifier: 9984047733402771

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