Journal article
Expression of cancer stem cell markers in tall cell variant papillary thyroid cancer identifies a molecular profile predictive of recurrence in classic papillary thyroid cancer
Surgery, Vol.171(1), pp.245-251
08/03/2021
DOI: 10.1016/j.surg.2021.03.076
Abstract
Tall cell variant of papillary thyroid carcinoma is an aggressive subtype of papillary thyroid carcinoma. We examined expression of cancer stem cell markers in tall cell variant compared with other well-differentiated thyroid cancers.
Expression of cancer stem cell markers was examined in 572 thyroid tumors from The Cancer Genome Atlas Thyroid Cancer database and tall cell variant and papillary thyroid carcinoma tumors by immunohistochemistry.
Expression of the PROM1 gene, encoding the cancer stem cell marker CD133, was elevated in tall cell variant compared to classic papillary thyroid carcinoma in a large cohort of unmatched samples from The Cancer Genome Atlas Thyroid Cancer database (P < .001). By immunohistochemistry in age and stage matched samples, CD133 protein was confirmed to be significantly increased in tall cell variant versus classic papillary thyroid carcinoma (P = .006). Analyzing all thyroid cancers, high PROM1 expression was associated with worse disease-specific survival. Optimal cutoffs were determined to define a tall cell variant-like cancer stem cell signature characterized by high PROM1, high ALDH1A3, and low CD24 expression. Classic papillary thyroid carcinoma with a tall cell variant-like gene signature had worse recurrence disease-free survival compared to classic papillary thyroid carcinoma with a non-tall cell variant signature (P = .02).
Tall cell variant of papillary thyroid carcinoma has increased expression of cancer stem cell markers compared to classic papillary thyroid carcinoma. The tall cell variant-like cancer stem cell gene signature identified a molecular subtype of classic papillary thyroid carcinoma that has a worse recurrence-free survival.
Details
- Title: Subtitle
- Expression of cancer stem cell markers in tall cell variant papillary thyroid cancer identifies a molecular profile predictive of recurrence in classic papillary thyroid cancer
- Creators
- Anna C Beck - University of IowaAnand Rajan - University of IowaShannon Landers - University of IowaSarah Kelley - University of IowaAndrew M Bellizzi - University of IowaGeeta Lal - University of IowaSonia L Sugg - University of IowaJames R Howe - University of IowaCarlos H Chan - University of IowaRonald J Weigel - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Surgery, Vol.171(1), pp.245-251
- Publisher
- Elsevier Inc
- DOI
- 10.1016/j.surg.2021.03.076
- ISSN
- 0039-6060
- eISSN
- 1532-7361
- Grant note
- DOI: 10.13039/100000002, name: National Institutes of Health, award: T32CA148062
- Language
- English
- Date published
- 08/03/2021
- Academic Unit
- Anatomy and Cell Biology; Biochemistry and Molecular Biology; Stead Family Department of Pediatrics; Radiation Oncology; Surgery; Molecular Physiology and Biophysics; Pathology
- Record Identifier
- 9984183988502771
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