Journal article
Expression of dystrophin-associated glycoproteins during human fetal muscle development: A preliminary immunocytochemical study
Neuromuscular disorders : NMD, Vol.4(4), pp.343-348
1994
DOI: 10.1016/0960-8966(94)90070-1
PMID: 7981591
Abstract
An immunocytochemical study was performed on quadriceps muscle from eight fetuses ranging from 12 weeks of gestation to term, using antibodies against the dystrophin-associated proteins, in order to evaluate the developmental expression of these proteins. For comparison, antibodies against dystrophin and utrophin were also used. The expression of the 59 kDa dystrophin-associated protein was simultaneous with that of dystrophin, which is also a subsarcolemmal protein. The extracellular glycoprotein of 156 kDa (α-dystroglycan) and the transmembrane glycoprotein of 43 kDa (β-dystroglycan) appeared to be expressed later. The transmembrane glycoproteins of 50 kDa (adhalin) and 35 kDa were fully expressed at an even later stage of fetal muscle development. This study suggests that the subsarcolemmal proteins may have an essential role in the assembly of the transmembrane and extracellular components of the dystrophin-glycoprotein complex during fetal muscle development. The knowledge obtained from observing the developmental expression of these proteins may contribute to the understanding of the molecular mechanism of their different involvement in muscle disorders.
Details
- Title: Subtitle
- Expression of dystrophin-associated glycoproteins during human fetal muscle development: A preliminary immunocytochemical study
- Creators
- F.M.S Tomé - INSERM U. 153 and CNRS ERS 064, 17 rue de Fer-à-Moulin, 75005 Paris, FranceK Matsumura - Howard Hughes Medical Institute and Department of Physiology and Biophysics, University of Iowa College of Medicine, Iowa City, Iowa 52242, U.S.AM Chevallay - INSERM U. 153 and CNRS ERS 064, 17 rue de Fer-à-Moulin, 75005 Paris, FranceK.P Campbell - Howard Hughes Medical Institute and Department of Physiology and Biophysics, University of Iowa College of Medicine, Iowa City, Iowa 52242, U.S.AM Fardeau - INSERM U. 153 and CNRS ERS 064, 17 rue de Fer-à-Moulin, 75005 Paris, France
- Resource Type
- Journal article
- Publication Details
- Neuromuscular disorders : NMD, Vol.4(4), pp.343-348
- Publisher
- Elsevier B.V
- DOI
- 10.1016/0960-8966(94)90070-1
- PMID
- 7981591
- ISSN
- 0960-8966
- eISSN
- 1873-2364
- Language
- English
- Date published
- 1994
- Academic Unit
- Neurology; Molecular Physiology and Biophysics; Iowa Neuroscience Institute
- Record Identifier
- 9984068374202771
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