Journal article
Expression of human nerve growth factor receptor on cells derived from all three germ layers
Experimental cell research, Vol.174(2), pp.533-539
1988
DOI: 10.1016/0014-4827(88)90323-0
PMID: 2828087
Abstract
Nerve growth factor (NGF) is a protein which promotes the survival and differentiation of neuronal cells
in vitro and plays an important role in neuronal development. In this study, we have examined the expression of the receptor for NGF (NGFR) in human neuronal and nonneuronal cells, both in tissue culture and
in vivo. In addition to cell lines derived from neuroblastoma, astrocytoma, and melanoma, all of which share a common neuroectodermal origin, NGFR was detected in a number of cultured cells of mesenchymal, epithelial, and hematopoietic derivation. Immunohistochemical analysis showed that NGFR is expressed in several nonneural human tissues, and the cell types in which NGFR was found include derivatives from all three germ layers. Thus, our findings demonstrate that NGFR is much more widely expressed in human cells and tissues than was previously thought.
Details
- Title: Subtitle
- Expression of human nerve growth factor receptor on cells derived from all three germ layers
- Creators
- Timothy M Thomson - Laboratory of Human Cancer Immunology, Sloan-Kettering Institute, New York, New York 10021 USAWolfgang J Rettig - Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, New York 10021 USAPilar Garin Chesa - Department of Pharmacology, New York University Medical School, New York, New York 10016 USASteven H Green - Lymphocyte Surface Marker Laboratory, Sloan-Kettering Institute, New York, New York 10021 USAAlfredo Carrato Mena - Lymphocyte Surface Marker Laboratory, Sloan-Kettering Institute, New York, New York 10021 USALloyd J Old - Laboratory of Human Cancer Immunology, Sloan-Kettering Institute, New York, New York 10021 USA
- Resource Type
- Journal article
- Publication Details
- Experimental cell research, Vol.174(2), pp.533-539
- Publisher
- Elsevier Inc
- DOI
- 10.1016/0014-4827(88)90323-0
- PMID
- 2828087
- ISSN
- 0014-4827
- eISSN
- 1090-2422
- Language
- English
- Date published
- 1988
- Academic Unit
- Biology; Otolaryngology
- Record Identifier
- 9984217423602771
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