Journal article
Expression of p16 and p53 in Intraepithelial Periocular Sebaceous Carcinoma
Ocular oncology and pathology, Vol.2(2), pp.71-75
12/2015
DOI: 10.1159/000439308
PMCID: PMC4847677
PMID: 27171611
Abstract
Purpose: Identifying intraepithelial sebaceous carcinoma cells in small periocular biopsies can be difficult, particularly in the conjunctiva. The goal of this study was to evaluate p53 and p16 immunohistochemistry as potential markers of intraepithelial sebaceous carcinoma.
Procedures: A total of 25 tumors, including 4 recurrent lesions, were stained for p16 and p53, with intensity scored as negative, weak, moderate or strong.
Results: Expression of p16 was detected in intraepithelial sebaceous carcinoma cells in 24 of the 25 cases (96%), with only 1 case showing weak immunoreactivity. Intraepithelial p53 immunoreactivity was present in 17 of 25 tumors (68%), but was weak in 3 cases. Expression levels remained relatively stable in primary and recurrent tumors, but varied in a few cases between intraepithelial and subepithelial sites.
Conclusions: Intraepithelial sebaceous carcinomas stained for p53 and p16 demonstrated moderate to strong immunoreactivity in 100% of cases for at least one of these proteins, suggesting that together they are useful markers for determining the extent of tumor spread. Of the two, p16 was immunoreactive in more cases than p53.
Details
- Title: Subtitle
- Expression of p16 and p53 in Intraepithelial Periocular Sebaceous Carcinoma
- Creators
- W. Robert Bell - The Johns Hopkins University School of Medicine, Baltimore, Md., USAKamaljeet Singh - The Johns Hopkins University School of Medicine, Baltimore, Md., USAAnand Rajan KD - The Johns Hopkins University School of Medicine, Baltimore, Md., USACharles G Eberhart - The Johns Hopkins University School of Medicine, Baltimore, Md., USA
- Resource Type
- Journal article
- Publication Details
- Ocular oncology and pathology, Vol.2(2), pp.71-75
- Publisher
- S. Karger AG
- DOI
- 10.1159/000439308
- PMID
- 27171611
- PMCID
- PMC4847677
- ISSN
- 2296-4681
- eISSN
- 2296-4657
- Language
- English
- Date published
- 12/2015
- Academic Unit
- Pathology
- Record Identifier
- 9984047646802771
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