Journal article
Expression of the Dengue Virus Type 2 NS5 Protein in a CD4+ T Cell Line Inhibits HIV Replication
The Journal of infectious diseases, Vol.198(6), pp.860-863
09/15/2008
DOI: 10.1086/591254
PMID: 18721058
Abstract
Human immunodeficiency virus (HIV) load is suppressed during dengue virus infection. The NS5A phosphoprotein of GB virus C (a related flavivirus) inhibits HIV replication in vitro. To determine whether the dengue virus NS5 protein inhibits HIV replication, CD4+ T cell lines expressing this protein were generated. HIV replication in dengue virus NS5—expressing cells decreased by >90% compared with control cells (P < .01), and this was mediated in part by decreased HIV coreceptor (CXCR4) expression and increased production of SDF-1. Thus, the dengue virus NS5 protein inhibits HIV replication in vitro, potentially explaining the reduction in HIV load observed during acute dengue virus infection.
Details
- Title: Subtitle
- Expression of the Dengue Virus Type 2 NS5 Protein in a CD4+ T Cell Line Inhibits HIV Replication
- Creators
- James H McLinden - Iowa City VA Medical Center and the University of Iowa, Iowa City, IowaJack T Stapleton - Iowa City VA Medical Center and the University of Iowa, Iowa City, IowaQing Chang - Iowa City VA Medical Center and the University of Iowa, Iowa City, IowaJinhua Xiang - Iowa City VA Medical Center and the University of Iowa, Iowa City, Iowa
- Resource Type
- Journal article
- Publication Details
- The Journal of infectious diseases, Vol.198(6), pp.860-863
- DOI
- 10.1086/591254
- PMID
- 18721058
- NLM abbreviation
- J Infect Dis
- ISSN
- 0022-1899
- eISSN
- 1537-6613
- Publisher
- The University of Chicago Press
- Language
- English
- Date published
- 09/15/2008
- Academic Unit
- Microbiology and Immunology; Infectious Diseases; Internal Medicine
- Record Identifier
- 9984094311002771
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