Expression of the neu gene-encoded protein (P185neu) in human non-small cell carcinomas of the lung

David B Weiner; Joanne Nordberg; Robert Robinson; Peter C Nowell; Adi  Gazdar; Mark I Greene; William V Williams; Jeffrey A Cohen; Jeffrey A. Kern

Expression of the neu gene-encoded protein (P185neu) in human non-small cell carcinomas of the lung

Journal article

Peer reviewed

Expression of the neu gene-encoded protein (P185neu) in human non-small cell carcinomas of the lung

David B Weiner, Joanne Nordberg, Robert Robinson, Peter C Nowell, Adi Gazdar, Mark I Greene, William V Williams, Jeffrey A Cohen and Jeffrey A. Kern

Cancer research (Chicago, Ill.), Vol.50(2), pp.421-425

1990

PMID: 1967224

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Abstract

The neu protooncogene is a recently described transforming gene originally isolated from ethylnitrosourea-induced rat neuroblastomas. We have examined the expression of the neu gene in human non-small cell lung carcinomas using immunoprecipitation and immunohistochemistry. The neu protein product (pl85M) was present in eight of 22 non-small cell carcinoma cell lines derived from human lung tumors. Expression of P185 was found in all histological subtypes of non-small cell carcinomas including large cell carcinomas, squamous cell carcinomas, and adenocarcinomas. Extension of these data to biopsy specimens of human lung tumors demonstrated that normal ciliated bronchial epithelium of the peripheral airways expressed P185 at low levels. Neoplastic cells in four of 12 adenocarcinomas and three of five squamous cell carcinomas also expressed pi85 at levels higher than the normal ciliated bronchial epithelium. Together these studies indicate that pi85 expression is a common feature of human lung tumors.

Tumors of the respiratory system and mediastinum

Biological and medical sciences

Medical sciences

Pneumology

Details

Title: Subtitle: Expression of the neu gene-encoded protein (P185neu) in human non-small cell carcinomas of the lung
Creators: David B Weiner - Univ. Pennsylvania school medicine, dep. pathology, Philadelphia PA, United States
Joanne Nordberg - Univ. Pennsylvania school medicine, dep. pathology, Philadelphia PA, United States
Robert Robinson - Univ. Pennsylvania school medicine, dep. pathology, Philadelphia PA, United States
Peter C Nowell - Univ. Pennsylvania school medicine, dep. pathology, Philadelphia PA, United States
Adi Gazdar - Univ. Pennsylvania school medicine, dep. pathology, Philadelphia PA, United States
Mark I Greene - Univ. Pennsylvania school medicine, dep. pathology, Philadelphia PA, United States
William V Williams - Univ. Pennsylvania school medicine, dep. pathology, Philadelphia PA, United States
Jeffrey A Cohen - Univ. Pennsylvania school medicine, dep. pathology, Philadelphia PA, United States
Jeffrey A. Kern - Univ. Pennsylvania school medicine, dep. pathology, Philadelphia PA, United States
Resource Type: Journal article
Publication Details: Cancer research (Chicago, Ill.), Vol.50(2), pp.421-425
Publisher: American Association for Cancer Research; Philadelphia, PA
PMID: 1967224
ISSN: 0008-5472
eISSN: 1538-7445
Language: English
Date published: 1990
Academic Unit: Oral Pathology, Radiology and Medicine; Pathology
Record Identifier: 9984047607002771

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