Journal article
Expression of three mouse homologs of the Drosophila segment polarity gene cubitus interruptus, Gli, Gli-2, and Gli-3, in ectoderm- and mesoderm-derived tissues suggests multiple roles during postimplantation development
Developmental biology, Vol.162(2), pp.402-413
04/1994
DOI: 10.1006/dbio.1994.1097
PMID: 8150204
Abstract
Three mouse genes, Gli, Gli-2, and Gli-3, which share a similar zinc finger domain with the products of the Drosophila segment polarity gene cubitus interruptus and the Caenorhabditis elegans sex-determining gene tra-1 were cloned and characterized. The expression patterns during postimplantation development of the three genes were analyzed by Northern blot, whole-mount, and section in situ hybridizations. Expression was first detected during gastrulation in both the ectoderm and mesoderm. Later in development, their expression became more restricted in various ectoderm- and mesoderm-derived tissues and was not detectable after completion of organogenesis. Interestingly, in the developing neural tube, Gli showed a narrow ventral domain of expression, whereas Gli-2 and Gli-3 showed a broad and dorsally restricted domain. Expression of these three Gli genes in various ectoderm- and mesoderm-derived tissues suggests that they play multiple roles during postimplantation development. Consistent with this hypothesis, a naturally occurring Gli-3 mutation, the mouse extra-toes mutant; shows defects in both mesoderm- and ectoderm-derived tissues.
Details
- Title: Subtitle
- Expression of three mouse homologs of the Drosophila segment polarity gene cubitus interruptus, Gli, Gli-2, and Gli-3, in ectoderm- and mesoderm-derived tissues suggests multiple roles during postimplantation development
- Creators
- Chi-Chung Hui - Division of Molecular and Developmental Biology, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, CanadaDiane SlusarskiKenneth A PlattRobert HolmgrenAlexandra L Joyner
- Resource Type
- Journal article
- Publication Details
- Developmental biology, Vol.162(2), pp.402-413
- Publisher
- United States
- DOI
- 10.1006/dbio.1994.1097
- PMID
- 8150204
- ISSN
- 0012-1606
- eISSN
- 1095-564X
- Language
- English
- Date published
- 04/1994
- Academic Unit
- Iowa Neuroscience Institute; Biology; Fraternal Order of Eagles Diabetes Research Center
- Record Identifier
- 9983991947602771
Metrics
25 Record Views