Journal article
Expression profiles of FABP4 and FABP5 in breast cancer: clinical implications and perspectives
Discover. Oncology, Vol.16(1), 357
03/19/2025
DOI: 10.1007/s12672-025-02117-x
PMCID: PMC11923334
PMID: 40106183
Abstract
The incidence of breast cancer continues to rise each year despite significant advances in diagnosis and treatment. Obesity-associated dysregulated lipid metabolism is believed to contribute to the increasing risk of breast cancer. However, the mechanisms linking lipid dysregulation to breast cancer risk and progression remain to be determined. The family of fatty acid binding proteins (FABPs) evolves to facilitate lipid transport and metabolism. As the predominant isoforms of FABP members expressed in breast tissue, adipose FABP (A-FABP, also known as FABP4) and epithelial FABP (E-FABP, FABP5) have been shown to play critical roles in breast carcinogenesis. In this study, we collected surgical breast tissue samples from 96 women with different subtypes of breast cancer and comprehensively analyzed the expression pattens of FABP4 and FABP5. We found that distinct expression profiles of FABP4 and FABP5 were associated with their unique roles in breast cancer development. FABP4, mainly expressed in breast stroma, especially in adipose tissue, likely supported neighboring tumor cell lymphovascular invasion through secretion from adipocytes. In contrast, FABP5, primarily expressed in epithelial-derived tumor cells, could promote tumor metastasis by enhancing lipid metabolism. Thus, elevated levels of FABP4 and FABP5 may serve as poor prognostic markers for breast cancer. Inhibiting the activity of FABP4 and/or FABP5 may offer a novel strategy for breast cancer therapy.
Details
- Title: Subtitle
- Expression profiles of FABP4 and FABP5 in breast cancer: clinical implications and perspectives
- Creators
- Xingshan Jiang - University of IowaYiqin Xiong - University of IowaJianyu Yu - University of IowaAnthony Avellino - University of IowaShanshan Liu - University of IowaXiaochun Han - University of IowaZhaohua Wang - University of IowaJonathan S. Shilyansky - University of IowaMelissa A. Curry - University of IowaJiaqing Hao - University of IowaEdward R. Sauter - Rockville, MD USAYi Huang - University of IowaSonia L. Sugg - University of IowaBing Li - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Discover. Oncology, Vol.16(1), 357
- DOI
- 10.1007/s12672-025-02117-x
- PMID
- 40106183
- PMCID
- PMC11923334
- NLM abbreviation
- Discov Oncol
- ISSN
- 2730-6011
- eISSN
- 2730-6011
- Publisher
- Springer US
- Grant note
- NIH
The authors would like to thank the Comparative Pathology Laboratory for histology services.
- Language
- English
- Date published
- 03/19/2025
- Academic Unit
- Hematology, Oncology, and Blood & Marrow Transplantation; Pathology; Surgery; Internal Medicine
- Record Identifier
- 9984801841702771
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