Journal article
Expression, purification, and detection of novel streptococcal superantigens
Methods in molecular biology (Clifton, N.J.), Vol.214, pp.33-43
2003
DOI: 10.1385/1-59259-367-4:033
PMID: 12489452
Abstract
Superantigens (SAgs) are a class of bacterial or viral proteins that aberrantly alter immune system function through simultaneous interaction with lateral surfaces of major histocompatibility (MHC) class II molecules on antigen presenting cells, and to particular variable regions of the T-cell antigen receptor (TCR) β-chain. Among the secreted virulence factors from group A streptococci are the streptococcal pyrogenic exotoxins (SPEs), also commonly known as erythrogenic toxins or scarlet fever toxins. Together with the enterotoxins and toxic shock syndrome toxin-1 (TSST-1) from Staphylococcus aureus, the SPEs belong to a larger family of related exotoxins collectively known as the “pyrogenic toxin” class of superantigens, which share functional activities, similar amino acid sequences, and conserved three-dimensional structures (1,2). Due to their notable association with scarlet fever and streptococcal toxic shock syndrome (TSS), SPE A (3,4) and SPE C (5) are generally considered to be the prototypical streptococcal superantigens.
Details
- Title: Subtitle
- Expression, purification, and detection of novel streptococcal superantigens
- Creators
- John K McCormick - Lawson Health Research Institute, Department of Microbiology and Immunology, University of Western Ontario, London, Ontario, CanadaPatrick M Schlievert
- Resource Type
- Journal article
- Publication Details
- Methods in molecular biology (Clifton, N.J.), Vol.214, pp.33-43
- Publisher
- United States
- DOI
- 10.1385/1-59259-367-4:033
- PMID
- 12489452
- ISSN
- 1064-3745
- eISSN
- 1940-6029
- Grant note
- HL36611 / NHLBI NIH HHS
- Language
- English
- Date published
- 2003
- Academic Unit
- Microbiology and Immunology; Internal Medicine
- Record Identifier
- 9984001159702771
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