Extent of Endoscopic Resection for Anterior Skull Base Tumors: An MRI-Based Volumetric Analysis

Ian J. Koszewski; Gregory Avey; Azam Ahmed; Lucas Leonhard; Matthew R. Hoffman; Timothy M. McCulloch

doi:10.1055/s-0036-1597137

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Extent of Endoscopic Resection for Anterior Skull Base Tumors: An MRI-Based Volumetric Analysis

Journal article

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Extent of Endoscopic Resection for Anterior Skull Base Tumors: An MRI-Based Volumetric Analysis

Ian J. Koszewski, Gregory Avey, Azam Ahmed, Lucas Leonhard, Matthew R. Hoffman and Timothy M. McCulloch

Journal of neurological surgery. Part B, Skull base, Vol.78(3), pp.227-234

12/21/2016

DOI: 10.1055/s-0036-1597137

PMCID: PMC5461163

PMID: 28593109

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https://europepmc.org/articles/pmc5461163View

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Abstract

Objective To determine the volume of ventral skull base tumor removed following endoscopic endonasal (EEA) resection using MRI-based volumetric analysis and to evaluate the inter-rater reliability of such analysis. Design Retrospective case series. Setting Academic tertiary care hospital. Participants EEA patients November 2012 to August 2015. Main Outcome Measures Volumetric analysis of pre- and immediately postoperative MR imaging was performed independently by two investigators. The percentage of total tumor resected was evaluated according to resection goal and tumor type. Results A total of 39 patients underwent resection. Intraclass correlation coefficients between the raters were 0.9988 for preoperative and 0.9819 for postoperative images. Tumors (and average percentage removed) included 17 nonsecreting pituitary adenomas (95.3%), 8 secreting pituitary adenomas (86.2%), 4 meningiomas (81.6%), 3 olfactory neuroblastomas (100%), 2 craniopharyngiomas (100%), 1 large B–cell lymphoma (90.5%), 1 germ cell neoplasm (48.3), 1 benign fibrous connective tissue mass (93.4%), 1 epidermoid cyst (68.4%), and 1 chordoma (100%). For tumors treated with intent for gross total resection, 96.9 ± 4.8% was removed. Conclusion EEAs achieved tumor resection rates of ∼97% when total resection was attempted. The radiographic finding of residual tumor is of uncertain clinical significance. The volumetric analysis employed in this study demonstrated high inter-rater reliability and could facilitate further study.

endonasal

endoscopic skull base surgery

extent of resection

Original

tumor volume

Details

Title: Subtitle: Extent of Endoscopic Resection for Anterior Skull Base Tumors: An MRI-Based Volumetric Analysis
Creators: Ian J. Koszewski - University of Wisconsin–Madison
Gregory Avey - University of Wisconsin–Madison
Azam Ahmed - University of Wisconsin–Madison
Lucas Leonhard - University of Wisconsin–Madison
Matthew R. Hoffman - University of Wisconsin School of Medicine and Public Health
Timothy M. McCulloch - University of Wisconsin–Madison
Resource Type: Journal article
Publication Details: Journal of neurological surgery. Part B, Skull base, Vol.78(3), pp.227-234
DOI: 10.1055/s-0036-1597137
PMID: 28593109
PMCID: PMC5461163
NLM abbreviation: J Neurol Surg B Skull Base
ISSN: 2193-6331
eISSN: 2193-634X
Publisher: Georg Thieme Verlag KG
Language: English
Date published: 12/21/2016
Academic Unit: Otolaryngology
Record Identifier: 9984366276502771

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