Journal article
Extinction, renewal, and spontaneous recovery of a spatial preference in the water maze
Behavioral neuroscience, Vol.117(5), pp.1017-1028
10/2003
DOI: 10.1037/0735-7044.117.5.1017
PMID: 14570551
Abstract
Four experiments with C57BL/6 mice investigated extinction of a spatial preference in the Morris water maze. In Experiment 1, a spatial preference was extinguished by exposing mice to the water maze in the absence of a platform but in the presence of the distal spatial cues. In Experiment 2, extinction occurred when the platform was removed from the pool, when it was presented in random locations, or when it was presented consistently in the opposite location. Contextual renewal (Experiment 3) and spontaneous recovery (Experiment 4) of spatial preferences argue against an interpretation of extinction in terms of unlearning and instead suggest that extinction in the water maze, like extinction in Pavlovian conditioning, suppresses the original association. Implications of these findings for theories of spatial learning and hippocampal function are discussed.
Details
- Title: Subtitle
- Extinction, renewal, and spontaneous recovery of a spatial preference in the water maze
- Creators
- K Matthew Lattal - Department of Biology, University of Pennsylvania, 3740 Hamilton Walk, Philadelphia, PA 19104, USA. kmlattal@sas.upenn.eduMichael T MullenTed Abel
- Resource Type
- Journal article
- Publication Details
- Behavioral neuroscience, Vol.117(5), pp.1017-1028
- Publisher
- United States
- DOI
- 10.1037/0735-7044.117.5.1017
- PMID
- 14570551
- ISSN
- 0735-7044
- eISSN
- 1939-0084
- Grant note
- T32 MH 14654 / NIMH NIH HHS P30 HD 26979 / NICHD NIH HHS F32 MH 12441 / NIMH NIH HHS P50 AG 0808012 / NIA NIH HHS P50 MH 64054-01 / NIMH NIH HHS R01 AG 18199 / NIA NIH HHS R01 MH 60244 / NIMH NIH HHS
- Language
- English
- Date published
- 10/2003
- Academic Unit
- Molecular Physiology and Biophysics; Psychiatry; Psychological and Brain Sciences; Iowa Neuroscience Institute; Neuroscience and Pharmacology; Biochemistry and Molecular Biology
- Record Identifier
- 9984065837802771
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