Extracellular matrix proteoglycan degradation by human alveolar macrophages and neutrophils

Stephen E McGowan; Rhinda J Thompson

doi:10.1152/jappl.1989.66.1.400

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Extracellular matrix proteoglycan degradation by human alveolar macrophages and neutrophils

Journal article

Peer reviewed

Extracellular matrix proteoglycan degradation by human alveolar macrophages and neutrophils

Stephen E McGowan and Rhinda J Thompson

Journal of applied physiology (1985), Vol.66(1), pp.400-409

01/1989

DOI: 10.1152/jappl.1989.66.1.400

PMID: 2917944

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Abstract

Degradation and restructuring of the elastin fiber network of the lung is a pivotal process in the pathogenesis of emphysema. Alveolar macrophages and neutrophils are probably directly involved in elastin degradation, but they may also indirectly influence elastin structure and function by altering other extracellular matrix components such as proteoglycans. In this study the mechanisms of proteoglycan degradation by human alveolar macrophages and neutrophils have been explored. Macrophages appear to utilize plasminogen in solubilizing 35SO4-labeled proteoglycans in extracellular matrix produced by neonatal rat vascular smooth muscle cells. Proteoglycan degradation by macrophages is significantly augmented in the presence of 1% human serum. In contrast, neutrophils apparently utilize intrinsic proteinases to solubilize extracellular matrix proteoglycans, and serum inhibits proteoglycan degradation by these cells. Persistent inflammation in the terminal airways of cigarette smokers may produce proteoglycan degradation and influence elastin fiber architecture where the earliest physiological and anatomic evidence of emphysema appears.

Sulfates - metabolism

Glycosaminoglycans - metabolism

Humans

Extracellular Matrix - metabolism

Proteoglycans - metabolism

Rats

Rats, Inbred Strains

Macrophages - metabolism

Animals

Pulmonary Alveoli - metabolism

Pulmonary Alveoli - cytology

Bronchoalveolar Lavage Fluid - cytology

Neutrophils - metabolism

Details

Title: Subtitle: Extracellular matrix proteoglycan degradation by human alveolar macrophages and neutrophils
Creators: Stephen E McGowan - Department of Internal Medicine, University of Iowa College of Medicine, Iowa City
Rhinda J Thompson - University of Iowa
Resource Type: Journal article
Publication Details: Journal of applied physiology (1985), Vol.66(1), pp.400-409
DOI: 10.1152/jappl.1989.66.1.400
PMID: 2917944
NLM abbreviation: J Appl Physiol (1985)
ISSN: 8750-7587
eISSN: 1522-1601
Publisher: United States
Language: English
Date published: 01/1989
Academic Unit: International Programs; Internal Medicine
Record Identifier: 9983984536302771

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