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Extracellular to Intracellular Body Water and Cognitive Function among Healthy Older and Younger Adults
Journal article   Open access   Peer reviewed

Extracellular to Intracellular Body Water and Cognitive Function among Healthy Older and Younger Adults

Jinhyun Lee and Richard K Shields
Journal of functional morphology and kinesiology, Vol.7(1), p.18
02/05/2022
DOI: 10.3390/jfmk7010018
PMCID: PMC8883954
PMID: 35225904
url
https://doi.org/10.3390/jfmk7010018View
Published (Version of record) Open Access

Abstract

Compromised cognitive function is associated with increased mortality and increased healthcare costs. Physical characteristics including height, weight, body mass index, sex, and fat mass are often associated with cognitive function. Extracellular to intracellular body water ratio offers an additional anthropometric measurement that has received recent attention because of its association with systemic inflammation, hypertension, and blood-brain barrier permeability. The purposes of this study were to determine whether extracellular to intracellular body water ratios are different between younger and older people and whether they are associated with cognitive function, including executive function and attention, working memory, and information processing speed. A total of 118 healthy people (39 older; 79 younger) participated in this study. We discovered that extracellular to intracellular body water ratio increased with age, was predictive of an older person's ability to inhibit information and stay attentive to a desired task (Flanker test; R = 0.24; < 0.001), and had strong sensitivity (83%) and specificity (91%) to detect a lower executive function score. These findings support that extracellular to intracellular body water ratio offers predictive capabilities of cognitive function, even in a healthy group of elderly people.
 cognitive function body composition blood–brain barrier aging inflammation

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