Journal article
Extranodal Diffuse Large B-Cell Lymphoma of Bone and Soft Tissue Presenting With Marked Lymphedema and Hypercalcemia
Curēus (Palo Alto, CA), Vol.14(2), e22025
02/08/2022
DOI: 10.7759/cureus.22025
PMCID: PMC8823701
PMID: 35155052
Abstract
Extranodal involvement is more prevalent in diffuse large B-cell lymphoma (DLBCL) compared to other non-Hodgkin lymphoma subtypes, with up to 40% of patients with early-stage disease having at least one extranodal site. Virtually any tissue can be involved, but primary skeletal muscle and bone DLBCL is exceedingly rare. Here we report a case of DLBCL of the humerus and proximal limb musculature in a Vietnam War combat veteran with significant Agent Orange exposure and untreated hepatitis C infection. The patient presented with 1,25-dihydroxyvitamin D3-mediated malignant hypercalcemia and massive soft tissue infiltration. He had an excellent treatment response to chemotherapy and involved field radiation therapy. Also, we discuss hepatitis C and Agent Orange in the context of the pathogenesis and management of DLBCL.
Details
- Title: Subtitle
- Extranodal Diffuse Large B-Cell Lymphoma of Bone and Soft Tissue Presenting With Marked Lymphedema and Hypercalcemia
- Creators
- Arafat Shabbir - Yale New Haven HospitalArsenije Kojadinovic - Icahn School of Medicine at Mount SinaiSanaz Gidfar - Guthrie FoundationPrabhjot S. Mundi - Columbia University
- Resource Type
- Journal article
- Publication Details
- Curēus (Palo Alto, CA), Vol.14(2), e22025
- DOI
- 10.7759/cureus.22025
- PMID
- 35155052
- PMCID
- PMC8823701
- NLM abbreviation
- Cureus
- ISSN
- 2168-8184
- eISSN
- 2168-8184
- Publisher
- Springer Nature
- Number of pages
- 5
- Language
- English
- Date published
- 02/08/2022
- Academic Unit
- Internal Medicine
- Record Identifier
- 9984695662502771
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