Extranodal marginal zone lymphoma of the dura mater with IgH/MALT1 translocation and review of literature

Sharathkumar Bhagavathi; Timothy C Greiner; Syed A Kazmi; Kai Fu; Warren G Sanger; Wing C Chan

doi:10.1007/s12308-008-0005-9

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Extranodal marginal zone lymphoma of the dura mater with IgH/MALT1 translocation and review of literature

Journal article

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Extranodal marginal zone lymphoma of the dura mater with IgH/MALT1 translocation and review of literature

Sharathkumar Bhagavathi, Timothy C Greiner, Syed A Kazmi, Kai Fu, Warren G Sanger and Wing C Chan

Journal of hematopathology, Vol.1(2), pp.131-137

09/2008

DOI: 10.1007/s12308-008-0005-9

PMCID: PMC2713483

PMID: 19669212

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Abstract

Primary central nervous system lymphoma (PCNSL) is an extranodal non-Hodgkin lymphoma involving brain, intraocular structures and spinal cord, without evidence of systemic disease. The majority of PCNSLs are diffuse large B-cell type. We encountered a rare case of primary dural marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT) with extension into the brain in a 59-year-old man. A magnetic resonance imaging scan showed a 22-mm tumor located in the left posterior temporal lobe extending from the dura. Histopathology revealed a lymphoplasmacytic infiltration of the dura and the brain parenchyma in a perivascular pattern. Immunohistochemical and in situ hybridization studies showed a B-cell phenotype with kappa light chain restriction. Fluorescent in situ hybridization study showed a t(14;18)(q32;q21) with immunoglobulin heavy-chain/MALT1 fusion. The molecular study for immunoglobulin heavy-chain gene rearrangement by polymerase chain reaction showed a clonal gene rearrangement.

Dura

FISH

Primary CNS

MALT1 translocation

MALT lymphoma

Case Report

Details

Title: Subtitle: Extranodal marginal zone lymphoma of the dura mater with IgH/MALT1 translocation and review of literature
Creators: Sharathkumar Bhagavathi - Department of Anatomic Pathology, William Beaumont Hospital, Royal Oak, MI 48076 USA
Timothy C Greiner - Department of Pathology and Microbiology, University of Nebraska Medical Center, 983135, Nebraska Medical Center, Omaha, NE 68198-3135 USA
Syed A Kazmi - Department of Pathology and Microbiology, University of Nebraska Medical Center, 983135, Nebraska Medical Center, Omaha, NE 68198-3135 USA
Kai Fu - Department of Pathology and Microbiology, University of Nebraska Medical Center, 983135, Nebraska Medical Center, Omaha, NE 68198-3135 USA
Warren G Sanger - Department of Cytogenetic, University of Nebraska Medical Center, 983135, Nebraska Medical Center, Omaha, NE 68198-3135 USA
Wing C Chan - Department of Pathology and Microbiology, University of Nebraska Medical Center, 983135, Nebraska Medical Center, Omaha, NE 68198-3135 USA
Resource Type: Journal article
Publication Details: Journal of hematopathology, Vol.1(2), pp.131-137
DOI: 10.1007/s12308-008-0005-9
PMID: 19669212
PMCID: PMC2713483
NLM abbreviation: J Hematop
ISSN: 1865-5785
eISSN: 1865-5785
Publisher: Springer-Verlag; Berlin/Heidelberg
Language: English
Date published: 09/2008
Academic Unit: Pathology
Record Identifier: 9984046814002771

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