Journal article
Extrapyramidal side-effects of antipsychotics in a randomised trial
British journal of psychiatry, Vol.193(4), pp.279-288
10/2008
DOI: 10.1192/bjp.bp.108.050088
PMCID: PMC2801816
PMID: 18827289
Abstract
Background
There are claims that second-generation antipsychotics produce fewer
extrapyramidal side-effects (EPS) compared with first-generation drugs.
Aims
To compare the incidence of treatment-emergent EPS between
second-generation antipsychotics and perphenazine in people with
schizophrenia.
Method
Incidence analyses integrated data from standardised rating scales and
documented use of concomitant medication or treatment discontinuation for EPS
events. Mixed model analyses of change in rating scales from baseline were
also conducted.
Results
There were no significant differences in incidence or change in rating
scales for parkinsonism, dystonia, akathisia or tardive dyskinesia when
comparing second-generation antipsychotics with perphenazine or comparing
between second-generation antipsychotics. Secondary analyses revealed greater
rates of concomitant antiparkinsonism medication among individuals on
risperidone and lower rates among individuals on quetiapine, and lower rates
of discontinuation because of parkinsonism among people on quetiapine and
ziprasidone. There was a trend for a greater likelihood of concomitant
medication for akathisia among individuals on risperidone and
perphenazine.
Conclusions
The incidence of treatment-emergent EPS and change in EPS ratings indicated
that there are no significant differences between second-generation
antipsychotics and perphenazine or between second-generation antipsychotics in
people with schizophrenia.
Details
- Title: Subtitle
- Extrapyramidal side-effects of antipsychotics in a randomised trial
- Creators
- Del D Miller - Columbia University College of Physicians and Surgeons, New York, New York, USAStanley N Caroff - Columbia University College of Physicians and Surgeons, New York, New York, USASonia M Davis - Columbia University College of Physicians and Surgeons, New York, New York, USARobert A Rosenheck - Columbia University College of Physicians and Surgeons, New York, New York, USAJoseph P McEvoy - Columbia University College of Physicians and Surgeons, New York, New York, USABruce L Saltz - Columbia University College of Physicians and Surgeons, New York, New York, USASilvana Riggio - Columbia University College of Physicians and Surgeons, New York, New York, USAMiranda H Chakos - Columbia University College of Physicians and Surgeons, New York, New York, USAMarvin S Swartz - Columbia University College of Physicians and Surgeons, New York, New York, USARichard S. E Keefe - Columbia University College of Physicians and Surgeons, New York, New York, USAT. Scott Stroup - Columbia University College of Physicians and Surgeons, New York, New York, USAJeffrey A Lieberman - Columbia University College of Physicians and Surgeons, New York, New York, USACATIE Investigators
- Resource Type
- Journal article
- Publication Details
- British journal of psychiatry, Vol.193(4), pp.279-288
- Publisher
- Royal College Of Psychiatrists
- DOI
- 10.1192/bjp.bp.108.050088
- PMID
- 18827289
- PMCID
- PMC2801816
- ISSN
- 0007-1250
- eISSN
- 1472-1465
- Language
- English
- Date published
- 10/2008
- Academic Unit
- Psychiatry
- Record Identifier
- 9984003931602771
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