Extratemporal quantitative MR volumetrics and neuropsychological status in temporal lobe epilepsy

Bruce Hermann; Michael Seidenberg; Brian Bell; Paul Rutecki; Raj D Sheth; Gary Wendt; Daniel O'Leary; Vince Magnotta

doi:10.1017/S1355617703930013

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Journal article

Extratemporal quantitative MR volumetrics and neuropsychological status in temporal lobe epilepsy

Bruce Hermann, Michael Seidenberg, Brian Bell, Paul Rutecki, Raj D Sheth, Gary Wendt, Daniel O'Leary and Vince Magnotta

Journal of the International Neuropsychological Society, Vol.9(3), pp.353-362

03/2003

DOI: 10.1017/S1355617703930013

PMID: 12666760

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Abstract

Neuropsychological studies of temporal lobe epilepsy have focused heavily on the nature and extent of memory dysfunction and its relationship to the neuropathological status of the hippocampus and related mesial temporal lobe structures. In this study, we examined whole brain and lobar quantitative MRI volumes and comprehensive neuropsychological performance in 58 patients with temporal lobe epilepsy and 62 healthy controls in order to determine (1) the nature and degree of extratemporal structural abnormalities in localization-related temporal lobe epilepsy: (2) the nature and degree of cognitive abnormalities outside of anterograde memory function; and (3) the relationship of volumetric abnormalities to neuropsychological status. Temporal lobe epilepsy patients exhibited significant reduction in the volume of adjusted (age, gender, height) total cerebral tissue (-5.8%), more evident in white (-9.8%) compared to gray matter (-3.0%) tissue volumes. Significant volumetric reductions were evident across frontal, temporal and parietal but not occipital lobe regions. Subarachnoid but not total ventricular CSF was significantly increased in epilepsy patients. Neuropsychological abnormality was generalized in nature, consistent with the generalized nature of the morphometric abnormalities, and reductions in cerebral tissue volumes were directly associated with poorer cognitive performance. In summary, patients with temporal lobe epilepsy exhibited clinically significant structural and functional abnormalities that extended outside the epileptogenic temporal lobe. The degree to which these structural and cognitive abnormalities are due to factors that cause the epilepsy, as opposed to reflecting the consequences of chronic epilepsy (e.g., duration and severity of epilepsy), remain to be determined.

Epilepsy, Temporal Lobe - psychology

Multivariate Analysis

Humans

Middle Aged

Cerebral Cortex - pathology

Magnetic Resonance Imaging - methods

Epilepsy, Temporal Lobe - physiopathology

Male

Functional Laterality

Intelligence Tests

Neuropsychological Tests

Psychiatric Status Rating Scales

Image Processing, Computer-Assisted

Cognition Disorders - etiology

Adolescent

Adult

Female

Cerebral Cortex - anatomy & histology

Epilepsy, Temporal Lobe - pathology

Details

Title: Subtitle: Extratemporal quantitative MR volumetrics and neuropsychological status in temporal lobe epilepsy
Creators: Bruce Hermann - Department of Neurology, University of Wisconsin, Madison 53792, USA. hermann@neurology.wisc.edu
Michael Seidenberg
Brian Bell
Paul Rutecki
Raj D Sheth
Gary Wendt
Daniel O'Leary
Vince Magnotta
Resource Type: Journal article
Publication Details: Journal of the International Neuropsychological Society, Vol.9(3), pp.353-362
DOI: 10.1017/S1355617703930013
PMID: 12666760
NLM abbreviation: J Int Neuropsychol Soc
ISSN: 1355-6177
eISSN: 1469-7661
Publisher: England
Grant note: M01 RR03186 / NCRR NIH HHS NS37738 / NINDS NIH HHS
Language: English
Date published: 03/2003
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Radiology; Psychiatry; Iowa Neuroscience Institute
Record Identifier: 9984003945902771

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