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Eye movements in amyotrophic lateral sclerosis and its mimics: a review with illustrative cases
Journal article   Open access   Peer reviewed

Eye movements in amyotrophic lateral sclerosis and its mimics: a review with illustrative cases

Colette Donaghy, Matthew J Thurtell, Erik P Pioro, J Mark Gibson and R John Leigh
Journal of neurology, neurosurgery and psychiatry, Vol.82(1), pp.110-116
01/2011
DOI: 10.1136/jnnp.2010.212407
PMID: 21097546
url
https://hal.archives-ouvertes.fr/hal-00594144View
Open Access

Abstract

Abnormal eye movements are increasingly recognised in patients with amyotrophic lateral sclerosis (ALS) and, when they occur, may provide insights into the pattern and pathogenesis of the disease process. In patients with disorders that mimic ALS, abnormal eye movements may point to the correct diagnosis. In both of these circumstances, systematic examination of eye movements and interpretation of the findings with reference to modern concepts of their neural substrate will aid diagnosis and suggest pathogenesis. Here, key points with illustrative case histories and eye movement records are highlighted.
Ocular Motility Disorders - etiology Eye Movements - physiology Supranuclear Palsy, Progressive - physiopathology Amyotrophic Lateral Sclerosis - physiopathology Humans Amyotrophic Lateral Sclerosis - diagnosis Fixation, Ocular - physiology Male Disease Progression Ophthalmoplegia - etiology Amyotrophic Lateral Sclerosis - complications Saccades Ocular Motility Disorders - diagnosis Aged Nystagmus, Pathologic - etiology Ocular Motility Disorders - physiopathology

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