Journal article
Eyeblink conditioning using cochlear nucleus stimulation as a conditioned stimulus in developing rats
Developmental psychobiology, Vol.50(7), pp.640-646
11/2008
DOI: 10.1002/dev.20331
PMCID: PMC2637147
PMID: 18688803
Abstract
Previous studies demonstrated that the development of auditory conditioned stimulus (CS) input to the cerebellum may be a neural mechanism underlying the ontogenetic emergence of eyeblink conditioning in rats. The current study investigated the role of developmental changes in the projections of the cochlear nucleus (CN) in the ontogeny of eyeblink conditioning using electrical stimulation of the CN as a CS. Rat pups were implanted with a bipolar stimulating electrode in the CN and given six 100-trial training sessions with a 300 ms stimulation train in the CN paired with a 10 ms periorbital shock unconditioned stimulus (US) on postnatal days (P) 17-18 or 24-25. Control groups were given unpaired presentations of the CS and US. Rats in both age groups that received paired training showed significant increases in eyeblink conditioned responses across training relative to the unpaired groups. The rats trained on P24-25, however, showed stronger conditioning relative to the group trained on P17-18. Rats with missed electrodes in the inferior cerebellar peduncle or in the cerebellar cortex did not show conditioning. The findings suggest that developmental changes in the CN projections to the pons, inferior colliculus, or medial auditory thalamus may be a neural mechanism underlying the ontogeny of auditory eyeblink conditioning.
Details
- Title: Subtitle
- Eyeblink conditioning using cochlear nucleus stimulation as a conditioned stimulus in developing rats
- Creators
- John H Freeman - Department of Psychology, University of Iowa, E11 Seashore Hall, Iowa City, Iowa 52242, USA. john-freeman@uiowa.eduJessica W Duffel
- Resource Type
- Journal article
- Publication Details
- Developmental psychobiology, Vol.50(7), pp.640-646
- DOI
- 10.1002/dev.20331
- PMID
- 18688803
- PMCID
- PMC2637147
- NLM abbreviation
- Dev Psychobiol
- ISSN
- 0012-1630
- eISSN
- 1098-2302
- Publisher
- United States
- Grant note
- NS38890 / NINDS NIH HHS R01 NS038890 / NINDS NIH HHS R01 NS038890-08 / NINDS NIH HHS R01 NS038890-07 / NINDS NIH HHS
- Language
- English
- Date published
- 11/2008
- Academic Unit
- Psychological and Brain Sciences; Iowa Neuroscience Institute
- Record Identifier
- 9984065752502771
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