F-18-Sodium Fluoride PET: History, Technical Feasibility, Mechanism of Action, Normal Biodistribution, and Diagnostic Performance in Bone Metastasis Detection Compared with Other Imaging Modalities

Kriti Ahuja; Houman Sotoudeh; Samuel J. Galgano; Ramandeep Singh; Nishant Gupta; Siddhartha Gaddamanugu; Gagandeep Choudhary

doi:10.2967/jnmt.119.234336

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F-18-Sodium Fluoride PET: History, Technical Feasibility, Mechanism of Action, Normal Biodistribution, and Diagnostic Performance in Bone Metastasis Detection Compared with Other Imaging Modalities

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F-18-Sodium Fluoride PET: History, Technical Feasibility, Mechanism of Action, Normal Biodistribution, and Diagnostic Performance in Bone Metastasis Detection Compared with Other Imaging Modalities

Kriti Ahuja, Houman Sotoudeh, Samuel J. Galgano, Ramandeep Singh, Nishant Gupta, Siddhartha Gaddamanugu and Gagandeep Choudhary

Journal of nuclear medicine technology, Vol.48(1), pp.9-16

03/01/2020

DOI: 10.2967/jnmt.119.234336

PMID: 31811067

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Abstract

The skeleton is the third most common site for metastasis overall, after the lungs and liver. Accurate diagnosis of osseous metastasis is critical for initial staging, treatment planning, restaging, treatment monitoring, and survival prediction. Currently, Tc-99(m)-methylene diphosphonate whole-body scanning is the cornerstone of imaging to detect osseous metastasis. Although F-18-sodium fluoride (F-18-NaF) was one of the oldest medical tracers for this purpose, it was replaced by other tracers because of their better physical properties, until recently. Continued development of PET scanners has opened a new era for F-18-NaF, and given its higher sensitivity, there have been increasing applications in imaging. In this review, we will discuss the history, technical aspects, radiobiology, and biodistribution of this tracer. Finally, we compare the accuracy of F-18-NaF PET with other conventional imaging methods for detection of osseous metastasis.

Life Sciences & Biomedicine

Radiology, Nuclear Medicine & Medical Imaging

Science & Technology

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Title: Subtitle: F-18-Sodium Fluoride PET: History, Technical Feasibility, Mechanism of Action, Normal Biodistribution, and Diagnostic Performance in Bone Metastasis Detection Compared with Other Imaging Modalities
Creators: Kriti Ahuja - University of Alabama at Birmingham
Houman Sotoudeh - University of Alabama at Birmingham
Samuel J. Galgano - University of Alabama at Birmingham
Ramandeep Singh - Massachusetts General Hospital
Nishant Gupta - Bassett Healthcare Network
Siddhartha Gaddamanugu - University of Alabama at Birmingham
Gagandeep Choudhary - University of Alabama at Birmingham
Resource Type: Journal article
Publication Details: Journal of nuclear medicine technology, Vol.48(1), pp.9-16
Publisher: Soc Nuclear Medicine Inc
DOI: 10.2967/jnmt.119.234336
PMID: 31811067
ISSN: 0091-4916
eISSN: 1535-5675
Number of pages: 8
Language: English
Date published: 03/01/2020
Academic Unit: Radiology
Record Identifier: 9984697626302771

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