Journal article
F14 Speeded tapping assesses progression of huntington's disease within one year—results from the track-HD study
Journal of neurology, neurosurgery and psychiatry, Vol.81(Suppl 1), pp.A27-A27
09/2010
DOI: 10.1136/jnnp.2010.222620.14
Abstract
Background Speeded (ST) and metronome (MT) tapping have been shown to be sensitive in distinguishing premanifest (preHD) and manifest (HD) stages of Huntington's disease (HD) in the cross-sectional analysis of the TRACK-HD study, and to detect an early motor phenotype even more than 14 years before predicted disease manifestation. Aims To investigate whether ST and MT are able to track disease progression within a 12 month follow-up period. Methods Participants from the four TRACK-HD sites (ST/MT: controls: 120/122, preHD: 117/118, HD: 117/121) were instructed to perform two tapping tasks with their non-dominant index finger. In ST, they had to tap at maximal speed for 10s; in MT, they were instructed to continue a given tapping rate of 1.8 Hz for 10s. After one year, the assessments were repeated. The annual change in performance of gene-carriers was compared to controls and to each other. The variability of tapping intervals expressed as logarithmic standard deviations was calculated for the primary outcome measures (ie, inter-onset interval (IOI) & tap duration (TD) in ST, inter-onset intervals (ΔIOI) & mid-tap interval (ΔMTI) in MT). Results The annual change in IOI and TD for ST showed significant results for HD versus controls and HD versus preHD. ΔIOI and ΔMTI, both MT variables, failed to make this distinction. Conclusions ST is able to detect changes in manifest HD within only one year of follow-up and may thus be applicable as an outcome measure for disease modifying clinical trials in early manifest HD. Possible changes in preHD may require longer follow-up periods or larger cohorts. The hypothesis that force-transducer-based MT and ST tasks may track the progression of a premanifest motor phenotype will be tested in the TRACK-HD study.
Details
- Title: Subtitle
- F14 Speeded tapping assesses progression of huntington's disease within one year—results from the track-HD study
- Creators
- N Bechtel - Department of Neurology, University of Münster, Münster, GermanyT Acharya - Department of Psychiatry, University of Iowa, Iowa City, Iowa, USAA Sturrock - Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, CanadaC Jauffret - Department of Genetics and Cytogenetics, and UPMC/INSERM UMR_S, APHP Groupe Hospitalier Pitié Salpêtrière, Paris, FranceM J Say - Institute of Neurology, University College London, Queen Square, London, UKA Patel - Institute of Neurology, University College London, Queen Square, London, UKJ E Read - Institute of Neurology, University College London, Queen Square, London, UKE t'Hart - Department of Neurology, Leiden University Medical Centre, Leiden, The NetherlandsS J A van den Bogaard - Department of Neurology, Leiden University Medical Centre, Leiden, The NetherlandsA Dürr - Department of Genetics and Cytogenetics, and UPMC/INSERM UMR_S, APHP Groupe Hospitalier Pitié Salpêtrière, Paris, FranceB R Leavitt - Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, CanadaR A C Roos - Department of Neurology, Leiden University Medical Centre, Leiden, The NetherlandsD R Langbehn - Department of Psychiatry, University of Iowa, Iowa City, Iowa, USAS J Tabrizi - Institute of Neurology, University College London, Queen Square, London, UKR Reilmann - Department of Neurology, University of Münster, Münster, Germany
- Resource Type
- Journal article
- Publication Details
- Journal of neurology, neurosurgery and psychiatry, Vol.81(Suppl 1), pp.A27-A27
- DOI
- 10.1136/jnnp.2010.222620.14
- ISSN
- 0022-3050
- eISSN
- 1468-330X
- Language
- English
- Date published
- 09/2010
- Academic Unit
- Psychiatry; Iowa Neuroscience Institute
- Record Identifier
- 9984066392302771
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