Journal article
F24 Differences in companion and subject ratings of subjects' behaviour using the frontal systems behaviour scale (FrSBe)- findings from the track-hd study
Journal of neurology, neurosurgery and psychiatry, Vol.81(Suppl 1), pp.A30-A30
09/2010
DOI: 10.1136/jnnp.2010.222620.24
Abstract
Background TRACK-HD is a multi-centre, longitudinal study investigating a range of motor, cognitive, neuropsychiatric and imaging measures as potential biomarkers for clinical trials in Huntington's disease (HD). The neuropsychiatric battery includes the Frontal Systems Behaviour Scale (FrSBe), a 46-item scale measuring behaviours associated with damage to the frontal lobes of the brain. In addition to subjects rating their own behaviour on the FrSBe, companions also rated subjects' behaviour. This provided an opportunity to investigate HD patients' insight into their behaviour by studying discrepancies between subject and companion ratings. Method 225 TRACK-HD subjects (62 premanifest gene carriers far from onset, 52 near to onset, 70 stage 1 HD and 41 stage 2 HD) completed the FrSBe. In addition, 164 companions (77 of premanifest subjects and 87 of early HD subjects) rated subjects' behaviour with the FrSBe. Results Companion ratings indicate a worsening of FrSBe scores with disease progression, especially in subjects with manifest HD. In contrast, subjects' self ratings did not show the same deterioration in FrSBe scores across the pre-HD and stage 1 subgroups, with the biggest discrepancy between subject and companion ratings at stage 1 HD. Surprisingly, self-ratings of stage 2 subjects were markedly worse than those at stage 1, almost eliminating this discrepancy between companion and self-ratings. Companion FrSBe ratings correlated more strongly with objective measures of cognitive and behavioural function than did subjects own ratings. Conclusion The existence of a discrepancy between companion and subjects' own ratings using the FrSBe in stage 1 HD but not in those with more advanced disease suggests that denial (as a psychological defence mechanism) is a more likely explanation than a loss of insight secondary to cognitive impairment.
Details
- Title: Subtitle
- F24 Differences in companion and subject ratings of subjects' behaviour using the frontal systems behaviour scale (FrSBe)- findings from the track-hd study
- Creators
- J Callaghan - University of Manchester, Manchester Academic Health Sciences Centre and Central Manchester University Hospitals NHS Foundation Trust, St Mary's Hospital, Manchester, UKD Craufurd - University of Manchester, Manchester Academic Health Sciences Centre and Central Manchester University Hospitals NHS Foundation Trust, St Mary's Hospital, Manchester, UKT Acharya - Departments of Psychiatry and Biostatistics (secondary), University of Iowa, Iowa City, USAA Dürr - Department of Genetics and Cytogenetics, and INSERM UMR S, APHP Hôpital de la Salpêtrière, Paris, FranceB R Leavitt - Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, CanadaR A C Roos - Department of Neurology, Leiden University Medical Centre, Leiden, The NetherlandsD R Langbehn - Departments of Psychiatry and Biostatistics (secondary), University of Iowa, Iowa City, USAJ C Stout - School of Psychology, Psychiatry, and Psychological Medicine, Monash University, Clayton Campus, Victoria, AustraliaS J Tabrizi - Institute of Neurology, University College London, Queen Square, London, UK
- Resource Type
- Journal article
- Publication Details
- Journal of neurology, neurosurgery and psychiatry, Vol.81(Suppl 1), pp.A30-A30
- DOI
- 10.1136/jnnp.2010.222620.24
- ISSN
- 0022-3050
- eISSN
- 1468-330X
- Language
- English
- Date published
- 09/2010
- Academic Unit
- Psychiatry; Orthopedics and Rehabilitation; Roy J. Carver Department of Biomedical Engineering; Iowa Neuroscience Institute
- Record Identifier
- 9984066379002771
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