FDG-PET imaging and the diagnosis of non-small cell lung cancer in a region of high histoplasmosis prevalence

Donita R Croft; John Trapp; Kemp Kernstine; Peter Kirchner; Brian Mullan; Jeffery Galvin; Michael W Peterson; Thomas Gross; Geoffrey McLennan; Jeffrey A Kern

doi:10.1016/S0169-5002(02)00023-5

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FDG-PET imaging and the diagnosis of non-small cell lung cancer in a region of high histoplasmosis prevalence

Journal article

Peer reviewed

FDG-PET imaging and the diagnosis of non-small cell lung cancer in a region of high histoplasmosis prevalence

Donita R Croft, John Trapp, Kemp Kernstine, Peter Kirchner, Brian Mullan, Jeffery Galvin, Michael W Peterson, Thomas Gross, Geoffrey McLennan and Jeffrey A Kern

Lung cancer (Amsterdam, Netherlands), Vol.36(3), pp.297-301

2002

DOI: 10.1016/S0169-5002(02)00023-5

PMID: 12009241

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Abstract

Study objective: Determine the sensitivity and specificity of [F-18]-fluorine-2-deoxy- d-glucose positron emission tomography (FDG-PET) in differentiating non-small cell lung cancer (NSCLC) from benign solitary pulmonary nodules (SPNs) in a region with a high endemic rate of histoplamosis. Design: Prospective, clinical study. Setting: University, tertiary referral hospital in the upper Mississippi River valley. Patients: Ninety patients with SPNs. Interventions: Independent interpretation of FDG-PET imaging, computed tomography and pathologic evaluation of the SPNs. Measurements and results: To detect malignant SPNs, FDG-PET imaging had a sensitivity of 93%, a specificity of 40%, a positive predictive value (PPV) of 88% and a negative predictive value (NPV) of 55%. Conclusions: In a region with a high prevalence of pulmonary fungal infection, FDG-PET is sensitive but has a low specificity and NPV for identifying NSCLC.In our study cohort, FDG-PET does not appear to reduce the need for SPN biopsies.

Positron-emission tomography

Histoplasmosis

Computed tomography

Infection, fungal

Carcinoma non-small-cell lung

Pulmonary nodule solitary

Lung neoplasms

Details

Title: Subtitle: FDG-PET imaging and the diagnosis of non-small cell lung cancer in a region of high histoplasmosis prevalence
Creators: Donita R Croft - The University of Iowa, Iowa City, IA, USA
John Trapp - P.C., Lincoln, NE, USA
Kemp Kernstine - The University of Iowa, Iowa City, IA, USA
Peter Kirchner - Department of Energy, Germantown, MD, USA
Brian Mullan - The University of Iowa, Iowa City, IA, USA
Jeffery Galvin - Armed Forces Institute of Pathology, Washington, DC, USA
Michael W Peterson - The University of Iowa, Iowa City, IA, USA
Thomas Gross - The University of Iowa, Iowa City, IA, USA
Geoffrey McLennan - The University of Iowa, Iowa City, IA, USA
Jeffrey A Kern - The University of Iowa, Iowa City, IA, USA
Resource Type: Journal article
Publication Details: Lung cancer (Amsterdam, Netherlands), Vol.36(3), pp.297-301
Publisher: Elsevier Ireland Ltd
DOI: 10.1016/S0169-5002(02)00023-5
PMID: 12009241
ISSN: 0169-5002
eISSN: 1872-8332
Language: English
Date published: 2002
Academic Unit: Radiology; Pulmonary, Critical Care, and Occupational Medicine; Internal Medicine
Record Identifier: 9984094622202771

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