Journal article
FDG-PET/CT in colorectal cancer: potential for vascular-metabolic imaging to provide markers of prognosis
European journal of nuclear medicine and molecular imaging, Vol.49(1), pp.371-384
04/10/2021
DOI: 10.1007/s00259-021-05318-y
PMID: 33837843
Abstract
This study assesses the potential for vascular-metabolic imaging with FluoroDeoxyGlucose (FDG)-Positron Emission Tomography/Computed Tomography (PET/CT) perfusion to provide markers of prognosis specific to the site and stage of colorectal cancer.
This prospective observational study comprised of participants with suspected colorectal cancer categorized as either (a) non-metastatic colon cancer (M0colon), (b) non-metastatic rectal cancer (M0rectum), or (c) metastatic colorectal cancer (M+). Combined FDG-PET/CT perfusion imaging was successfully performed in 286 participants (184 males, 102 females, age: 69.60 ± 10 years) deriving vascular and metabolic imaging parameters. Vascular and metabolic imaging parameters alone and in combination were investigated with respect to overall survival.
A vascular-metabolic signature that was significantly associated with poorer survival was identified for each patient group: M0colon - high Total Lesion Glycolysis (TLG) with increased Permeability Surface Area Product/Blood Flow (PS/BF), Hazard Ratio (HR) 3.472 (95% CI: 1.441-8.333), p = 0.006; M0rectum - high Metabolic Tumour Volume (MTV) with increased PS/BF, HR 4.567 (95% CI: 1.901-10.970), p = 0.001; M+ participants, high MTV with longer Time To Peak (TTP) enhancement, HR 2.421 (95% CI: 1.162-5.045), p = 0.018. In participants with stage 2 colon cancer as well as those with stage 3 rectal cancer, the vascular-metabolic signature could stratify the prognosis of these participants.
Vascular and metabolic imaging using FDG-PET/CT can be used to synergise prognostic markers. The hazard ratios suggest that the technique may have clinical utility.
Details
- Title: Subtitle
- FDG-PET/CT in colorectal cancer: potential for vascular-metabolic imaging to provide markers of prognosis
- Creators
- Shih-Hsin Chen - Department of Nuclear Medicine, Keelung Chang Gung Memorial Hospital, Keelung, TaiwanKenneth Miles - Division of Medicine, Research Department of Imaging, University College London (UCL), London, UKStuart A Taylor - Centre for Medical Imaging, University College London, London, UKBalaji Ganeshan - Division of Medicine, Research Department of Imaging, University College London (UCL), London, UKManuel Rodriquez - Department of Research Pathology, Cancer Institute, UCL, London, UKFrancesco Fraioli - University College London Hospitals (UCLH) NHS Foundation Trust, Surgery and Cancer Board, Imaging Division, University College Hospital (UCH), London, UKSimon Wan - University College London Hospitals (UCLH) NHS Foundation Trust, Surgery and Cancer Board, Imaging Division, University College Hospital (UCH), London, UKAsim Afaq - University of Iowa, RadiologyRobert Shortman - Department of Nuclear Medicine, Keelung Chang Gung Memorial Hospital, Keelung, TaiwanDarren Walls - Division of Medicine, Research Department of Imaging, University College London (UCL), London, UKLuke Hoy - Division of Medicine, Research Department of Imaging, University College London (UCL), London, UKRaymond Endozo - University College London Hospitals (UCLH) NHS Foundation Trust, Surgery and Cancer Board, Imaging Division, University College Hospital (UCH), London, UKAman Bhargava - Institute of Health Barts and London Medical School, Queen Mary University of London (QMUL), London, UKMatthew Hanson - Barking, Havering and Redbridge University Hospitals NHS Trust, Division of Cancer and Clinical Support, Queens and King George Hospitals, Essex, UKJoseph Huang - University of Iowa, Statistics and Actuarial ScienceSherif Raouf - Radiotherapy Department, Barts Cancer Centre, St Bartholomew's Hospital, West Smithfield, London, UKDaren Francis - Royal Free London NHS Foundation Trust, Department of Colorectal Surgery, Barnet and Chase Farm Hospitals, London, UKShahab Siddiqi - Mid Essex Hospital Services NHS Trust, Department of Lower GI Surgery and Coloproctology, Broomfield Hospital, Essex, UKTan Arulampalam - East Suffolk and North Essex NHS Foundation Trust, Department of Surgery & Department of Clinical Oncology, Colchester General Hospital, Essex, UKBruce Sizer - East Suffolk and North Essex NHS Foundation Trust, Department of Surgery & Department of Clinical Oncology, Colchester General Hospital, Essex, UKMichael Machesney - Barts Health NHS Trust, Cancer Clinical Board, Colorectal Surgery, Whipps Cross Hospital, London, UKNicholas Reay-Jones - East and North Hertfordshire NHS Trust, Colorectal Surgery, Queen Elizabeth II Hospital, Hertfordshire, UKSanjay Dindyal - East and North Hertfordshire NHS Trust, Colorectal Surgery, Lister Hospital, Hertfordshire, UKTony Ng - School of Cancer & Pharmaceutical Sciences, Kings College London (KCL), London, UK. tony.ng@kcl.ac.ukAshley Groves - Division of Medicine, Research Department of Imaging, University College London (UCL), London, UK. a.groves@ucl.ac.uk
- Resource Type
- Journal article
- Publication Details
- European journal of nuclear medicine and molecular imaging, Vol.49(1), pp.371-384
- DOI
- 10.1007/s00259-021-05318-y
- PMID
- 33837843
- NLM abbreviation
- Eur J Nucl Med Mol Imaging
- ISSN
- 1619-7070
- eISSN
- 1619-7089
- Grant note
- DOI: 10.13039/501100012317, name: UCLH Biomedical Research Centre
- Language
- English
- Date published
- 04/10/2021
- Academic Unit
- Radiology
- Record Identifier
- 9984130695402771
Metrics
27 Record Views