Journal article
FGF21 Is a Sugar-Induced Hormone Associated with Sweet Intake and Preference in Humans
Cell metabolism, Vol.25(5), pp.1045-1053.e6
05/02/2017
DOI: 10.1016/j.cmet.2017.04.009
PMID: 28467924
Abstract
The liking and selective ingestion of palatable foods—including sweets—is biologically controlled, and dysfunction of this regulation may promote unhealthy eating, obesity, and disease. The hepatokine fibroblast growth factor 21 (FGF21) reduces sweet consumption in rodents and primates, whereas knockout of Fgf21 increases sugar consumption in mice. To investigate the relevance of these findings in humans, we genotyped variants in the FGF21 locus in participants from the Danish Inter99 cohort (n = 6,514) and examined their relationship with a detailed range of food and ingestive behaviors. This revealed statistically significant associations between FGF21 rs838133 and increased consumption of candy, as well as nominal associations with increased alcohol intake and daily smoking. Moreover, in a separate clinical study, plasma FGF21 levels increased acutely after oral sucrose ingestion and were elevated in fasted sweet-disliking individuals. These data suggest the liver may secrete hormones that influence eating behavior.
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•Human FGF21 variants are associated with increased sweet consumption•These variants do not correlate with obesity, T2DM, or glucose intolerance•Circulating FGF21 is increased by sucrose consumption•Sweet-disliking individuals have elevated FGF21 levels
What is the molecular basis for a “sweet tooth”? In a combined clinical and genetic study, Søberg, Sandholt, and colleagues link the hepatokine FGF21 to increased sweet consumption in humans, potentially by acting on the central reward system.
Details
- Title: Subtitle
- FGF21 Is a Sugar-Induced Hormone Associated with Sweet Intake and Preference in Humans
- Creators
- Susanna Søberg - Section for Metabolic Imaging and Liver Metabolism, Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, DenmarkCamilla H Sandholt - Section of Metabolic Genetics, Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, DenmarkNaja Z Jespersen - Centre of Inflammation and Metabolism and Physical Activity Research, Rigshospitalet, University Hospital of Copenhagen, 2100 Copenhagen, DenmarkUlla Toft - Research Centre for Prevention and Health, Centre for Health, Capital Region of Denmark, 2600 Glostrup, DenmarkAnja L Madsen - Research Centre for Prevention and Health, Centre for Health, Capital Region of Denmark, 2600 Glostrup, DenmarkStephanie von Holstein-Rathlou - Section for Metabolic Imaging and Liver Metabolism, Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, DenmarkTrisha J Grevengoed - Section for Metabolic Imaging and Liver Metabolism, Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, DenmarkKarl B Christensen - Section of Biostatistics, Department of Public Health, University of Copenhagen, 2200 Copenhagen, DenmarkWender L.P Bredie - Department of Food Science, University of Copenhagen, 1958 Copenhagen, DenmarkMatthew J Potthoff - Department of Pharmacology and Fraternal Order of Eagles Diabetes Research Center, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USAThomas P.J Solomon - School of Sport, Exercise, and Rehabilitation Sciences, Institute of Metabolism and Systems Research, University of Birmingham, Edgbaston Birmingham B15 2TT, UKCamilla Scheele - Centre of Inflammation and Metabolism and Physical Activity Research, Rigshospitalet, University Hospital of Copenhagen, 2100 Copenhagen, DenmarkAllan Linneberg - Research Centre for Prevention and Health, Centre for Health, Capital Region of Denmark, 2600 Glostrup, DenmarkTorben Jørgensen - Research Centre for Prevention and Health, Centre for Health, Capital Region of Denmark, 2600 Glostrup, DenmarkOluf Pedersen - Section of Metabolic Genetics, Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, DenmarkTorben Hansen - Section of Metabolic Genetics, Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, DenmarkMatthew P Gillum - Section for Metabolic Imaging and Liver Metabolism, Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, DenmarkNiels Grarup - Section of Metabolic Genetics, Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark
- Resource Type
- Journal article
- Publication Details
- Cell metabolism, Vol.25(5), pp.1045-1053.e6
- Publisher
- Elsevier Inc
- DOI
- 10.1016/j.cmet.2017.04.009
- PMID
- 28467924
- ISSN
- 1550-4131
- eISSN
- 1932-7420
- Grant note
- DOI: 10.13039/501100004836, name: Danish Council for Independent Research, award: 4092-00240B; DOI: 10.13039/501100009708, name: Novo Nordisk Foundation, award: NNF15CC0018486; name: Novo; name: Rigshospitalets Forskningsfund; DOI: 10.13039/501100011747, name: Novo Nordisk Foundation Center for Basic Metabolic Research; DOI: 10.13039/501100007437, name: TrygFonden; DOI: 10.13039/501100001732, name: Danish National Research Foundation, award: DNRF55; DOI: 10.13039/100007398, name: Danish Council for Strategic Research, award: 09 – 067009, 09 – 075724; DOI: 10.13039/501100009708, name: Novo Nordisk Foundation
- Language
- English
- Date published
- 05/02/2017
- Academic Unit
- Neurology; Iowa Neuroscience Institute; Neuroscience and Pharmacology
- Record Identifier
- 9984040010202771
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