FHA-RING ubiquitin ligases in cell division cycle control

L Brooks III; E G Heimsath Jr; G L Loring; C Brenner

doi:10.1007/s00018-008-8220-1

Back

FHA-RING ubiquitin ligases in cell division cycle control

Journal article

Peer reviewed

FHA-RING ubiquitin ligases in cell division cycle control

L Brooks III, E G Heimsath Jr, G L Loring and C Brenner

Cellular and molecular life sciences : CMLS, Vol.65(21), pp.3458-3466

11/2008

DOI: 10.1007/s00018-008-8220-1

PMCID: PMC2588411

PMID: 18597043

Files and links (1)

url

https://www.ncbi.nlm.nih.gov/pmc/articles/2588411View

Open Access

Abstract

Despite the common occurrence of forkhead associated (FHA) phosphopeptide-binding domains and really interesting new gene (RING) E3 ubiquitin ligase domains, gene products containing both an N-terminal FHA domain and C-terminal RING domain constitute a highly distinctive intersection. Characterized FHA-RING ligases include the two vertebrate proteins, Checkpoint with FHA and RING (Chfr) and RING finger 8 (Rnf8), as well as three fungal proteins, Defective in mitosis (Dma1), Chf1 and Chf2. These FHA-RING ligases play roles in negative regulation of the cell division cycle, apparently by coupling protein phosphorylation events to specific ubiquitylation of target proteins. Here, the available data on upstream and downstream regulation of and by FHA-RING ligases are reviewed.

DNA Repair

Schizosaccharomyces pombe Proteins - chemistry

ADAM Proteins - physiology

Humans

Neoplasm Proteins - physiology

Structure-Activity Relationship

Ubiquitin-Protein Ligases - physiology

Cell Cycle Proteins - chemistry

Poly-ADP-Ribose Binding Proteins

Ubiquitination

Schizosaccharomyces pombe Proteins - physiology

Protein Structure, Tertiary

DNA-Binding Proteins - physiology

Neoplasm Proteins - chemistry

Ubiquitin-Protein Ligases - chemistry

DNA-Binding Proteins - chemistry

Protein Interaction Mapping

Cell Division - physiology

Tumor Suppressor Proteins - physiology

Sequence Alignment

Models, Biological

Cell Cycle - physiology

Protein Processing, Post-Translational

Saccharomyces cerevisiae Proteins - physiology

Cell Cycle Proteins - physiology

Genes, cdc

Schizosaccharomyces - cytology

Saccharomyces cerevisiae Proteins - chemistry

Details

Title: Subtitle: FHA-RING ubiquitin ligases in cell division cycle control
Creators: L Brooks III - Dartmouth–Hitchcock Medical Center
E G Heimsath Jr
G L Loring
C Brenner
Resource Type: Journal article
Publication Details: Cellular and molecular life sciences : CMLS, Vol.65(21), pp.3458-3466
DOI: 10.1007/s00018-008-8220-1
PMID: 18597043
PMCID: PMC2588411
NLM abbreviation: Cell Mol Life Sci
ISSN: 1420-682X
eISSN: 1420-9071
Publisher: Switzerland
Grant note: GM081665 / NIGMS NIH HHS R01 GM081665 / NIGMS NIH HHS R01 GM081665-01S1 / NIGMS NIH HHS R01 GM081665-02 / NIGMS NIH HHS
Language: English
Date published: 11/2008
Academic Unit: Biochemistry and Molecular Biology; Internal Medicine
Record Identifier: 9983788598302771

Metrics

18 Record Views

25 Times Cited - Web of Science