Journal article
FOLFOX-4 stop and go and capecitabine maintenance chemotherapy in the treatment of metastatic colorectal cancer
Oncology, Vol.70(5), pp.345-350
01/01/2006
DOI: 10.1159/000098107
PMID: 17179728
Abstract
Objective: Patients with metastatic colorectal cancer (MCC) usually receive FOLFOX-4, or other oxaliplatin (L-HOP)-based regimens, until the occurrence of progressive disease, with an increase in the incidence of neurotoxicity which is correlated to the cumulative dose of L-HOP. The aim of this study was to evaluate if FOLFOX-4 stop and go and capecitabine maintenance chemotherapy is associated with a low incidence of severe neurotoxicity in the treatment of MCC patients. Methods: Thirty-three patients were treated with FOLFOX-4 (L-HOP 85 mg/m2 day 1, leucovorin 200 mg/m2, 5-fluorouracil bolus 400 mg/m2 and 22 h 600 mg/m2 days 1 and 2, every 2 weeks). Patients who achieved objective response (OR) or stable disease (SD) then received oral capecitabine 2,500 mg/m2 days 1–14 every 3 weeks; L-HOP was reintroduced as soon as progression occurred. Results: Twenty-eight of the 29 patients who achieved OR or SD then received capecitabine. FOLFOX-4 was reintroduced in 18 patients (56.2%). The median response duration (RD) was 9.2 months and median progression-free survival (PFS) was 8.6 months. Twenty-eight patients (87.5%) had peripheral neuropathy during treatment, but grade 3 neurotoxicity was observed in only 1 patient (3.1%). Conclusions: FOLFOX-4 stop and go and capecitabine maintenance chemotherapy was associated with a very low incidence of grade 3 neurotoxicity. Although the number of patients enrolled was far too low for a definite conclusion, RD and PFS were comparable to those usually reported in the treatment of MCC patients.
Details
- Title: Subtitle
- FOLFOX-4 stop and go and capecitabine maintenance chemotherapy in the treatment of metastatic colorectal cancer
- Creators
- Roberto Petrioli - University of SienaLoretta Paolelli - University of SienaMarco Lorenzi - University of SienaGuido Francini - University of SienaStefania Marsili - University of SienaSerenella Civitelli - University of SienaEdoardo Francini - University of SienaTommaso Cioppa - University of SienaFranco Roviello - University of SienaRaffaele Nettuno - Geriatric Oncology, S. Felice Hospital, Caserta, ItalyChiara Intrivici - University of PalermoGabriello Tanzini - University of Siena
- Resource Type
- Journal article
- Publication Details
- Oncology, Vol.70(5), pp.345-350
- DOI
- 10.1159/000098107
- PMID
- 17179728
- ISSN
- 0030-2414
- eISSN
- 1423-0232
- Publisher
- Karger
- Number of pages
- 6
- Language
- English
- Date published
- 01/01/2006
- Academic Unit
- Internal Medicine
- Record Identifier
- 9985221143902771
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