Journal article
FREE RADICAL PRODUCTION BY CHLORPROMAZINE SULFOXIDE, AN ESR SPIN‐TRAPPING AND FLASH PHOTOLYSIS STUDY
Photochemistry and photobiology, Vol.44(1), pp.5-10
07/1986
DOI: 10.1111/j.1751-1097.1986.tb03556.x
PMID: 3018808
Abstract
— Using the spin‐trapping technique we have investigated the photolysis of chlorpromazine sulfoxide and promazine sulfoxide. Photolysis of these sulfoxides in aqueous solution resulted in a species which is capable of oxidizing ascorbate, cysteine, glutathione, NADH, and azide by one electron, in addition to extracting hydrogen atoms from ethyl alcohol and dimethyl sulfoxide. These oxidations were not dependent on the presence of dissolved oxygen. The oxidizing species is proposed to be the hydroxyl free radical arising from the homolytic cleavage of the S‐O bond of the sulfoxide. Flash photolysis of the chlorpromazine and promazine sulfoxides demonstrated the formation of cation radicals consistent with the loss of the hydroxyl radical from the sulfoxides. In addition we present a simple direct method for the quantitative synthesis of promazine and chlorpromazine sulfoxides from the parent promazine derivatives.
Details
- Title: Subtitle
- FREE RADICAL PRODUCTION BY CHLORPROMAZINE SULFOXIDE, AN ESR SPIN‐TRAPPING AND FLASH PHOTOLYSIS STUDY
- Creators
- Garry R BuettnerAnn G MottenRobert D HallColin F Chignell
- Resource Type
- Journal article
- Publication Details
- Photochemistry and photobiology, Vol.44(1), pp.5-10
- Publisher
- Blackwell Publishing Ltd; Oxford, UK
- DOI
- 10.1111/j.1751-1097.1986.tb03556.x
- PMID
- 3018808
- ISSN
- 0031-8655
- eISSN
- 1751-1097
- Number of pages
- 6
- Language
- English
- Date published
- 07/1986
- Academic Unit
- Radiation Oncology
- Record Identifier
- 9984046913902771
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