Journal article
FRIENDLY Regulates Mitochondrial Distribution, Fusion, and Quality Control in Arabidopsis
Plant physiology (Bethesda), Vol.166(2), pp.808-U517
2014
DOI: 10.1104/pp.114.243824
PMCID: PMC4213110
PMID: 25165398
Abstract
Mitochondria are defining components of most eukaryotes. However, higher plant mitochondria differ biochemically, morphologically, and dynamically from those in other eukaryotes. FRIENDLY, a member of the CLUSTERED MITOCHONDRIA superfamily, is conserved among eukaryotes and is required for correct distribution of mitochondria within the cell. We sought to understand how disruption of FRIENDLY function in Arabidopsis (Arabidopsis thaliana) leads to mitochondrial clustering and the effects of this aberrant chondriome on cell and whole-plant physiology. We present evidence for a role of FRIENDLY in mediating intermitochondrial association, which is a necessary prelude to mitochondrial fusion. We demonstrate that disruption of mitochondrial association, motility, and chondriome structure in friendly affects mitochondrial quality control and leads to mitochondrial stress, cell death, and strong growth phenotypes.
Details
- Title: Subtitle
- FRIENDLY Regulates Mitochondrial Distribution, Fusion, and Quality Control in Arabidopsis
- Creators
- Amr M El Zawily - Department of BiologyMarkus Schwarzlaender - Institute of Crop Science and Resource Conservation [Bonn]Iris Finkemeier - Plant Proteomics GroupIain G Johnston - Department of Mathematics [Imperial College London]Abdelilah Benamar - Institut de Recherche en Horticulture et SemencesYongguo Cao - Plant Biotechnology InstituteClemence Gissot - Department of Mathematics [Imperial College London]Andreas J Meyer - Institute of Crop Science and Resource Conservation [Bonn]Ken Wilson - Department of BiologyRaju Datla - Plant Biotechnology InstituteDavid Macherel - Institut de Recherche en Horticulture et SemencesNick S Jones - Department of Mathematics [Imperial College London]David Logan - Institut de Recherche en Horticulture et Semences
- Resource Type
- Journal article
- Publication Details
- Plant physiology (Bethesda), Vol.166(2), pp.808-U517
- Publisher
- American Society of Plant Biologists
- DOI
- 10.1104/pp.114.243824
- PMID
- 25165398
- PMCID
- PMC4213110
- ISSN
- 0032-0889
- eISSN
- 1532-2548
- Language
- English
- Date published
- 2014
- Academic Unit
- Biology
- Record Identifier
- 9984217420802771
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