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Facilitative glucose transporter Glut1 is actively excluded from rod outer segments
Journal article   Open access   Peer reviewed

Facilitative glucose transporter Glut1 is actively excluded from rod outer segments

Sidney M Gospe III, Sheila A Baker and Vadim Y Arshavsky
Journal of cell science, Vol.123(21), pp.3639-3644
11/01/2010
DOI: 10.1242/jcs.072389
PMCID: PMC2964109
PMID: 20923839
url
https://doi.org/10.1242/jcs.072389View
Published (Version of record) Open Access

Abstract

Photoreceptors are among the most metabolically active cells in the body, relying on both oxidative phosphorylation and glycolysis to satisfy their high energy needs. Local glycolysis is thought to be particularly crucial in supporting the function of the photoreceptor's light-sensitive outer segment compartment, which is devoid of mitochondria. Accordingly, it has been commonly accepted that the facilitative glucose transporter Glut1 responsible for glucose entry into photoreceptors is localized in part to the outer segment plasma membrane. However, we now demonstrate that Glut1 is entirely absent from the rod outer segment and is actively excluded from this compartment by targeting information present in its cytosolic C-terminal tail. Our data indicate that glucose metabolized in the outer segment must first enter through other parts of the photoreceptor cell. Consequently, the entire energy supply of the outer segment is dependent on diffusion of energy-rich substrates through the thin connecting cilium that links this compartment to the rest of the cell.
 Short Reports Glucose transport Glut1 Photoreceptor

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