Journal article
Factors Affecting Visual Field Outcomes in the Idiopathic Intracranial Hypertension Treatment Trial
Journal of neuro-ophthalmology, Vol.36(1), pp.6-12
03/2016
DOI: 10.1097/WNO.0000000000000327
PMID: 26618282
Abstract
To determine the prevalence of visual field (VF) performance failures (PF) and treatment failures (TFs), and identify factors associated with PFs in the Idiopathic Intracranial Hypertension Treatment Trial (IIHTT). A total of 165 participants from 38 sites with idiopathic intracranial hypertension (IIH) and mild visual loss were randomized to either acetazolamide-plus diet or placebo-plus diet. The IIHTT Visual Field Reading Center evaluated 2950 Swedish Interactive Threshold Algorithm Standard 24-2 VFs from the enrolled participants. A TF was defined when the participant's VF mean deviation (MD) worsened ≥2 to 3 dB from the average baseline MD (range of -2 to -7 dB) with a second retest confirming the visual deterioration. A PF was determined when the participant's: 1) VF results met TF criteria but were not confirmed on retest, 2) deterioration was confirmed on retest but the IIHTT Adjudication Committee concluded a TF was clinically unlikely. TF was detected in 7/165 (4%) of the participants and PF was detected in 35/165 (21%) of the participants on at least 1 examination. Four of the 35 PFs were adjudicated for TF, however based on clinical review by the adjudication committee and a third retest, they were judged as PFs. Of the 2,950 total IIHTT VF examinations, 2.7% met PF criteria. PF was confirmed in 21% of subjects and in 2.7% of the total number of VF examinations and was reversible on repeat testing. We recommend retesting when perimetric worsening occurs in otherwise clinically stable or improving IIH patients.
Details
- Title: Subtitle
- Factors Affecting Visual Field Outcomes in the Idiopathic Intracranial Hypertension Treatment Trial
- Creators
- Kimberly E Cello - University of California, DavisJohn L Keltner - University of California, DavisChris A JohnsonMichael WallNORDIC Idiopathic Intracranial Hypertension Study Group
- Resource Type
- Journal article
- Publication Details
- Journal of neuro-ophthalmology, Vol.36(1), pp.6-12
- Publisher
- United States
- DOI
- 10.1097/WNO.0000000000000327
- PMID
- 26618282
- ISSN
- 1070-8022
- eISSN
- 1536-5166
- Grant note
- 3U10EY017281-01A1S2 / NEI NIH HHS 1U10EY017281-01A1 / NEI NIH HHS 1U10EY017387-01A1S1 / NEI NIH HHS 3U10EY017281-01A1S1 / NEI NIH HHS 1U10EY017387-01A1 / NEI NIH HHS
- Language
- English
- Date published
- 03/2016
- Academic Unit
- Neurology; Ophthalmology and Visual Sciences
- Record Identifier
- 9983979950402771
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