Factors Associated With Refusal of Intramuscular Vitamin K in Normal Newborns

Jaspreet Loyal; James A Taylor; Carrie A Phillipi; Neera K Goyal; Kelly E Wood; Carl Seashore; Beth King; Eve Colson; Veronika Shabanova; Eugene D Shapiro; BORN investigators

doi:10.1542/peds.2017-3743

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Factors Associated With Refusal of Intramuscular Vitamin K in Normal Newborns

Journal article

Open access

Peer reviewed

Factors Associated With Refusal of Intramuscular Vitamin K in Normal Newborns

Jaspreet Loyal, James A Taylor, Carrie A Phillipi, Neera K Goyal, Kelly E Wood, Carl Seashore, Beth King, Eve Colson, Veronika Shabanova, Eugene D Shapiro, …

Pediatrics (Evanston), Vol.142(2), p.1

08/2018

DOI: 10.1542/peds.2017-3743

PMCID: PMC6317553

PMID: 30030367

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https://europepmc.org/articles/pmc6317553View

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Abstract

Refusal of intramuscular (IM) vitamin K administration by parents is an emerging problem. Our objective was to assess the frequency of and factors associated with refusal of IM vitamin K administration in well newborns in the United States. We determined the number of newborns admitted to well newborn units whose parents refused IM vitamin K administration in the Better Outcomes through Research for Newborns network and, in a nested patient-control study, identified factors associated with refusal of IM vitamin K administration by using a multiple logistic regression model. Of 102 878 newborns from 35 Better Outcomes through Research for Newborns sites, parents of 638 (0.6%) refused IM vitamin K administration. Frequency of refusal at individual sites varied from 0% to 2.3%. Exclusive breastfeeding (adjusted odds ratio [aOR] = 3.4; 95% confidence interval [CI]: 2.1-5.5), non-Hispanic white race and/or ethnicity (aOR = 1.7; 95% CI: 1.2-2.4), female sex (aOR = 1.6; 95% CI: 1.2-2.3), gestational age (aOR = 1.2; 95% CI: 1.1-1.4), and mother's age (aOR = 1.05; 95% CI: 1.02-1.08) were significantly associated with refusal of IM vitamin K administration. Refusal of the administration of both ocular prophylaxis and hepatitis B vaccine was also strongly associated with refusal of IM vitamin K administration (aOR = 88.7; 95% CI: 50.4-151.9). Refusal of IM vitamin K by parents of newborns is a significant problem. Interventions to minimize risks to these newborns are needed.

Adolescent

Adult

Female

Humans

Infant, Newborn

Injections, Intramuscular

Male

Middle Aged

Parents - psychology

Treatment Refusal - psychology

Treatment Refusal - trends

United States - epidemiology

Vitamin K - administration & dosage

Vitamin K Deficiency Bleeding - epidemiology

Vitamin K Deficiency Bleeding - prevention & control

Vitamin K Deficiency Bleeding - psychology

Young Adult

Details

Title: Subtitle: Factors Associated With Refusal of Intramuscular Vitamin K in Normal Newborns
Creators: Jaspreet Loyal - Yale University
James A Taylor - University of Washington
Carrie A Phillipi - Oregon Health & Science University
Neera K Goyal - Nemours Foundation
Kelly E Wood - University of Iowa
Carl Seashore - University of North Carolina at Chapel Hill
Beth King - Academic Pediatric Association
Eve Colson - Yale University
Veronika Shabanova - Yale University
Eugene D Shapiro - Yale University
BORN investigators
Resource Type: Journal article
Publication Details: Pediatrics (Evanston), Vol.142(2), p.1
DOI: 10.1542/peds.2017-3743
PMID: 30030367
PMCID: PMC6317553
NLM abbreviation: Pediatrics
ISSN: 0031-4005
eISSN: 1098-4275
Grant note: UL1 TR000142 / NCATS NIH HHS
Language: English
Date published: 08/2018
Academic Unit: Stead Family Department of Pediatrics; Hospital Medicine
Record Identifier: 9984353840002771

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