Journal article
Factors Controlling Aldosterone Secretion during Hypoxemia in Fetal Lambs
Pediatric research, Vol.18(7), pp.607-611
07/1984
DOI: 10.1203/00006450-198407000-00008
PMID: 6089082
Abstract
Summary: Factors modulating the fetal aldosterone response to hypoxemia were studied in three groups of chronically catheterized fetal lambs between 131 and 143 days of gestation (term, 145 days). One group (control group) received an infusion of 5% dextrose in water; the second group (captopril-treated group) was given captopril, an inhibitor of angiotensin-converting enzyme; the third group (captopril plus dexamethasone-treated group) received dexamethasone in addition to captopril. In all groups of fetuses, hypoxemia was associated with a significant increase in plasma K+ concentration (+0.7 ± 0.1 meq/liter). In control fetuses, changes in plasma aldosterone concentration during hypoxemia correlated closely with changes in plasma K+ concentration r = 0.79; P < 0.001) and with changes in plasma angiotensin II concentration (r = 0.77; P < 0.001). In the captopril-treated fetuses, the rise in plasma aldosterone concentration during hypoxemia correlated closely with plasma K+ (r = 0.79; P < 0.001) but not with plasma angiotensin II values (r = 0.17). No significant correlation was found between percent changes in maternal aldosterone and percent changes in fetal aldosterone during hypoxemia and following recovery (r = 0.36; P>0.1) in captopril-treated fetuses. Administration of dexamethasone to fetuses receiving captopril completely inhibited the rise in plasma aldosterone associated with hypoxemia. Taken together, the present results suggest that the rise in plasma aldosterone during hypoxemia is not related to the level of activity of the renin-angiotensin system but depends probably on the increased secretion of adrenocorticotrophin by the fetus. It is also suggested that maternal placental transfer of aldosterone is not an important factor controlling the rise in fetal plasma aldosterone concentration during hypoxemia.
Details
- Title: Subtitle
- Factors Controlling Aldosterone Secretion during Hypoxemia in Fetal Lambs
- Creators
- Jean E Robillard - University of IowaNancy A Ayres - University of IowaR Ariel GomezKenneth T Nakamura - University of IowaFred G Smith - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Pediatric research, Vol.18(7), pp.607-611
- DOI
- 10.1203/00006450-198407000-00008
- PMID
- 6089082
- ISSN
- 0031-3998
- eISSN
- 1530-0447
- Number of pages
- 5
- Language
- English
- Date published
- 07/1984
- Academic Unit
- Molecular Physiology and Biophysics; Nephrology, Dialysis and Transplantation; Stead Family Department of Pediatrics; Medicine Administration
- Record Identifier
- 9984774212602771
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