Journal article
Factors affecting maternal participation in the genetic component of the National Birth Defects Prevention Study-United States, 1997-2007
Genetics in medicine, Vol.16(4), pp.329-337
04/2014
DOI: 10.1038/gim.2013.143
PMCID: PMC4471475
PMID: 24071796
Abstract
As epidemiological studies expand to examine gene-environment interaction effects, it is important to identify factors associated with participation in genetic studies. The National Birth Defects Prevention Study is a multisite case-control study designed to investigate environmental and genetic risk factors for major birth defects. The National Birth Defects Prevention Study includes maternal telephone interviews and mailed buccal cell self-collection kits. Because subjects can participate in the interview, independent of buccal cell collection, detailed analysis of factors associated with participation in buccal cell collection was possible.
Multivariable logistic regression models were used to identify the factors associated with participation in the genetic component of the study.
Buccal cell participation rates varied by race/ethnicity (non-Hispanic whites, 66.9%; Hispanics, 60.4%; and non-Hispanic blacks, 47.3%) and study site (50.2-74.2%). Additional monetary incentive following return of buccal cell kit and shorter interval between infant's estimated date of delivery and interview were associated with increased participation across all racial/ethnic groups. Higher education and delivering an infant with a birth defect were associated with increased participation among non-Hispanic whites and Hispanics.
Factors associated with participation varied by race/ethnicity. Improved understanding of factors associated with participation may facilitate strategies to increase participation, thereby improving generalizability of study findings.
Details
- Title: Subtitle
- Factors affecting maternal participation in the genetic component of the National Birth Defects Prevention Study-United States, 1997-2007
- Creators
- Jill Glidewell - 1] National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, Georgia, USA Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta, Georgia, USAJennita Reefhuis - National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, Georgia, USASonja A Rasmussen - National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia, USAAlison Woomert - Department of Epidemiology, University of North Carolina Gillings School of Global Public Health, Chapel Hill, North Carolina, USACharlotte Hobbs - Department of Pediatrics, University of Arkansas for Medical Sciences College of Medicine, Little Rock, Arkansas, USAPaul A Romitti - Department of Epidemiology, University of Iowa College of Public Health, Iowa City, Iowa, USAKrista S Crider - National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
- Resource Type
- Journal article
- Publication Details
- Genetics in medicine, Vol.16(4), pp.329-337
- Publisher
- United States
- DOI
- 10.1038/gim.2013.143
- PMID
- 24071796
- PMCID
- PMC4471475
- ISSN
- 1098-3600
- eISSN
- 1530-0366
- Grant note
- CC999999 / Intramural CDC HHS P30 ES005605 / NIEHS NIH HHS U01 DD001035 / NCBDD CDC HHS
- Language
- English
- Date published
- 04/2014
- Academic Unit
- Epidemiology; Biostatistics
- Record Identifier
- 9983996067002771
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