Factors associated with dopaminergic drug-related pathological gambling in parkinson disease

Valerie VOON; Teri THOMSEN; Janis M MIYASAKI; Minella DE SOUZA; Ariel SHAFRO; Susan H FOX; Sarah DUFF-CANNING; Anthony E LANG; Mateusz ZUROWSKI

doi:10.1001/archneur.64.2.212

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Factors associated with dopaminergic drug-related pathological gambling in parkinson disease

Journal article

Open access

Peer reviewed

Factors associated with dopaminergic drug-related pathological gambling in parkinson disease

Valerie VOON, Teri THOMSEN, Janis M MIYASAKI, Minella DE SOUZA, Ariel SHAFRO, Susan H FOX, Sarah DUFF-CANNING, Anthony E LANG and Mateusz ZUROWSKI

Archives of neurology (Chicago), Vol.64(2), pp.212-216

2007

DOI: 10.1001/archneur.64.2.212

PMID: 17296836

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Abstract

Objective: To evaluate factors associated with pathological gambling (PG) in Parkinson disease (PD). Design: Case-control study. Setting: Outpatient tertiary clinic. Patients Twenty-one patients with idiopathic PD with PG after the patients began receiving medications compared with a consecutive sample of 42 patients with idiopathic PD without compulsive behaviors. Main outcome measures: Clinical features, comorbid psychiatric and substance use disorders, personality traits, and impulsivity scores. Results: Patients with PG had a younger age at PD onset (P = .006), higher novelty seeking (P<.001), medication-induced hypomania or mania (P = .001), impaired planning (P = .002), or a personal or immediate family history of alcohol use disorders (P = .002). Novelty seeking, a personal or immediate family history of alcohol use disorders, and younger age at PD onset accurately predicted PG at 83.7% in a logistic regression model, with the model accounting for 62% of the variance. Conclusions: Patients with PD having a younger age at PD onset, higher novelty seeking traits, and a personal or family history of alcohol use disorders may have a greater risk for PG with dopamine agonists.

Neurology

Neuropharmacology

Pharmacology. Drug treatments

Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases

Biological and medical sciences

Anticonvulsants. Antiepileptics. Antiparkinson agents

Medical sciences

Details

Title: Subtitle: Factors associated with dopaminergic drug-related pathological gambling in parkinson disease
Creators: Valerie VOON - National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Md, United States
Teri THOMSEN - Department of Psychiatry, Toronto Western Hospital, Toronto, Ontario, Canada
Janis M MIYASAKI - Division of Neurology, Toronto Western Hospital, Toronto, Ontario, Canada
Minella DE SOUZA - Department of Psychiatry, Toronto Western Hospital, Toronto, Ontario, Canada
Ariel SHAFRO - Department of Psychiatry, Toronto Western Hospital, Toronto, Ontario, Canada
Susan H FOX - Division of Neurology, Toronto Western Hospital, Toronto, Ontario, Canada
Sarah DUFF-CANNING - Division of Neurology, Toronto Western Hospital, Toronto, Ontario, Canada
Anthony E LANG - Division of Neurology, Toronto Western Hospital, Toronto, Ontario, Canada
Mateusz ZUROWSKI - Department of Psychiatry, Toronto Western Hospital, Toronto, Ontario, Canada
Resource Type: Journal article
Publication Details: Archives of neurology (Chicago), Vol.64(2), pp.212-216
DOI: 10.1001/archneur.64.2.212
PMID: 17296836
NLM abbreviation: Arch Neurol
ISSN: 0003-9942
eISSN: 1538-3687
Publisher: American Medical Association; Chicago, IL
Language: English
Date published: 2007
Academic Unit: Neurology
Record Identifier: 9984020718102771

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