Journal article
Factors associated with healthcare personnel uptake of updated COVID-19 vaccine doses in the United States
Preventive medicine reports, Vol.58, 103233
10/2025
DOI: 10.1016/j.pmedr.2025.103233
PMCID: PMC12491726
PMID: 41050854
Abstract
Evaluate factors associated with United States (US) healthcare personnel (HCP) uptake of an updated COVID-19 vaccine.
We analyzed data from 887 US HCP enrolled between September 25, 2023, and April 17, 2024, in a multisite case-control COVID-19 vaccine effectiveness study. Sociodemographic and attitudinal data were collected via standardized surveys, and vaccination status was verified using source documentation.
Overall, 188 (21.2 %) HCP received the updated vaccine. HCP aged 50–64 years (adjusted odds ratio [aOR] 2.02, 95 % CI: 1.11–3.67) versus ages 18–29, and HCP with undergraduate (aOR 3.75, 95 % CI: 1.97–7.12) or graduate degrees (aOR 7.73, 95 % CI: 4.10–14.55) versus high school/some college had higher odds of vaccination. Nurses and nurse assistants had lower odds (aOR 0.48, 95 % CI: 0.30–0.76) versus other job roles. Vaccinated HCP were more likely than unvaccinated HCP to cite concerns about personal infection (89.9 % vs. 44.6 %), infecting family/friends (96.3 % vs. 56.0 %), vaccine availability (63.3 % vs. 18.9 %), and peer-reviewed literature (56.4 % vs. 28.3 %) as important influences. These factors remained consistent with findings from a prior vaccine season.
Vaccine access, education, and peer-reviewed information remain drivers of HCP vaccine uptake. Strategies should address occupational disparities and emphasize transmission risks.
•Older healthcare personnel had higher odds of booster receipt.•Healthcare personnel with graduate degrees had higher odds of booster receipt.•Infection risk, family safety, vaccine access, and literature influenced decisions.•Factors remained consistent with findings from a prior vaccine season.•Availability and peer-reviewed info are key to healthcare personnel vaccine uptake.
Details
- Title: Subtitle
- Factors associated with healthcare personnel uptake of updated COVID-19 vaccine doses in the United States
- Creators
- Eric Kontowicz - Department of Emergency Medicine, University of Iowa Hospitals & Clinics, Iowa City, IA, USAKari K. Harland - University of Iowa, Emergency MedicineAmy Stubbs - University of Missouri–Kansas CityDavid Beiser - University of ChicagoIan Plumb - Centers for Disease Control and PreventionAnusha Krishnadasan - University of California, Los AngelesDavid A. Talan - University of California, Los AngelesNicholas M. Mohr - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Preventive medicine reports, Vol.58, 103233
- DOI
- 10.1016/j.pmedr.2025.103233
- PMID
- 41050854
- PMCID
- PMC12491726
- NLM abbreviation
- Prev Med Rep
- ISSN
- 2211-3355
- eISSN
- 2211-3355
- Publisher
- Elsevier Inc
- Grant note
- Centers for Disease Control and Prevention (CDC): U01CK000480 Institute for Clinical and Translational Science at the University of Iowa through a grant from the National Center for Advancing Translational Sciences of the National Institutes of Health: UM1TR004403 National Center for Advancing Translational Sciences of the National Institutes of Health: UM1TR004403
This project was funded by the Centers for Disease Control and Prevention (CDC) (U01CK000480) . The project was additionally supported by the Institute for Clinical and Translational Science at the University of Iowa through a grant from the National Center for Advancing Translational Sciences of the National Institutes of Health (UM1TR004403) .
- Language
- English
- Date published
- 10/2025
- Academic Unit
- Epidemiology; Emergency Medicine; Anesthesia; Injury Prevention Research Center; Law Faculty; Internal Medicine
- Record Identifier
- 9984962541102771
Metrics
38 Record Views