Journal article
Factors associated with improved toxicity and tolerability of intraperitoneal chemotherapy in advanced-stage epithelial ovarian cancers
American Journal of Obstetrics and Gynecology, Vol.208(6), pp.501.e1-501.e7
06/2013
DOI: 10.1016/j.ajog.2013.03.012
PMID: 23507546
Abstract
We sought to evaluate the toxicity and tolerability of the intraperitoneal/intravenous regimen by comparing the modified regimen that is used at the Moffitt Cancer Center vs the published findings of the Gynecologic Oncology Group Study 172. Using the Moffitt database, we evaluated the outcomes of patients who underwent primary optimal cytoreduction for stage IIC-IV epithelial ovarian, tubal, and peritoneal carcinoma followed by the intent-to-treat with intraperitoneal/intravenous chemotherapy. National Cancer Institute Common Terminology Criteria for Adverse Events (version 3.0) was used to grade adverse events. We analyzed patient data from 2006-2011 and identified 69 patients who met our inclusion criteria. The most frequent grade 3/4 toxicities were neutropenia (48%), gastrointestinal (9%), metabolic (9%), and infection (5%). Remaining toxicities occurred in <5% of patients. Patients received a greater number of cycles compared with the Gynecologic Oncology Group Study 172 (4.28 vs 3.66, respectively; P = .0088). With the use of supportive care and the preemptive management of established side-effects, the associated toxicities and tolerability of intraperitoneal chemotherapy can be improved.
Details
- Title: Subtitle
- Factors associated with improved toxicity and tolerability of intraperitoneal chemotherapy in advanced-stage epithelial ovarian cancers
- Creators
- Patrick Teefey - Department of Obstetrics and Gynecology, University of South Florida, Tampa, FLNadim Bou Zgheib - Department of Obstetrics and Gynecology, University of South Florida, Tampa, FLSachin M Apte - Division of Gynecologic Oncology, Department of Women's Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FLJesus Gonzalez-Bosquet - Division of Gynecologic Oncology, Department of Women's Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FLPatricia L Judson - Division of Gynecologic Oncology, Department of Women's Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FLWilliam S Roberts - Division of Gynecologic Oncology, Department of Women's Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FLJohnathan M Lancaster - Division of Gynecologic Oncology, Department of Women's Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FLRobert M Wenham - Division of Gynecologic Oncology, Department of Women's Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL
- Resource Type
- Journal article
- Publication Details
- American Journal of Obstetrics and Gynecology, Vol.208(6), pp.501.e1-501.e7
- Publisher
- Mosby, Inc
- DOI
- 10.1016/j.ajog.2013.03.012
- PMID
- 23507546
- ISSN
- 0002-9378
- eISSN
- 1097-6868
- Language
- English
- Date published
- 06/2013
- Academic Unit
- Obstetrics and Gynecology
- Record Identifier
- 9983931406202771
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