Factors associated with initial tidal volume selection during neonatal volume-targeted ventilation in two NICUs: a retrospective cohort study

Lindsey A Knake; Mhd Wael Alrifai; Allison B McCoy; Scott O Guthrie; Adam Wright; Christoph U Lehmann; L Dupree Hatch III

doi:10.1038/s41372-022-01362-0

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Factors associated with initial tidal volume selection during neonatal volume-targeted ventilation in two NICUs: a retrospective cohort study

Journal article

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Peer reviewed

Factors associated with initial tidal volume selection during neonatal volume-targeted ventilation in two NICUs: a retrospective cohort study

Lindsey A Knake, Mhd Wael Alrifai, Allison B McCoy, Scott O Guthrie, Adam Wright, Christoph U Lehmann and L Dupree Hatch III

Journal of perinatology, Vol.42(6), pp.756-760

06/2022

DOI: 10.1038/s41372-022-01362-0

PMCID: PMC8917474

PMID: 35279706

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Abstract

To quantify initial tidal volume (VT) during neonatal volume-targeted ventilation (VTV) and to characterize the agreement of initial VT with the limited-evidence available. We performed a multi-center retrospective observational cohort study in two Neonatal Intensive Care Units evaluating 313 infants who received VTV as the initial ventilation modality prior to postnatal day 14. We generated descriptive statistics and performed multivariable logistic regression analysis to determine factors associated with initial VT use that agreed with available literature. 154 (49%) infants received an initial VT of 5.0 mL/kg (median 5.0 mL/kg, IQR 5.0-5.1). 45 (14%) infants received an initial VT that was congruent with available literature. A birth weight of 700 -<1250 g was significantly associated with an initial VT in agreement with VT literature (aOR 9.4, 95% CI 1.7-50.4). Most infants receive an initial VT of 5.0 mL/kg.

Humans

Infant

Infant, Newborn

Intensive Care Units, Neonatal

Lung

Respiration, Artificial

Retrospective Studies

Tidal Volume

Details

Title: Subtitle: Factors associated with initial tidal volume selection during neonatal volume-targeted ventilation in two NICUs: a retrospective cohort study
Creators: Lindsey A Knake - University of Iowa
Mhd Wael Alrifai - Vanderbilt University
Allison B McCoy - Vanderbilt University
Scott O Guthrie - Jackson-Madison County General Hospital
Adam Wright - Vanderbilt University
Christoph U Lehmann - The University of Texas Southwestern Medical Center
L Dupree Hatch III - Vanderbilt University Medical Center
Resource Type: Journal article
Publication Details: Journal of perinatology, Vol.42(6), pp.756-760
DOI: 10.1038/s41372-022-01362-0
PMID: 35279706
PMCID: PMC8917474
ISSN: 0743-8346
eISSN: 1476-5543
Language: English
Date published: 06/2022
Academic Unit: Stead Family Department of Pediatrics; Neonatology
Record Identifier: 9984353847502771

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