Journal article
Factors associated with meniscal extrusion in knees with or at risk for osteoarthritis: the Multicenter Osteoarthritis study
Radiology, Vol.264(2), pp.494-503
08/2012
DOI: 10.1148/radiol.12110986
PMCID: PMC3401352
PMID: 22653191
Abstract
To assess the associations of meniscal tears, knee mal-alignment, cartilage damage, knee effusion, and body mass index with meniscal extrusion.
The Multicenter Osteoarthritis study is an observational study of individuals who have or are at risk for knee osteoarthritis (OA). The HIPAA-compliant protocol was approved by the institutional review boards of all participating centers, and written informed consent was obtained from all patients. All subjects with available baseline knee radiographs and magnetic resonance (MR) images were included. MR imaging assessment of meniscal morphologic characteristics, meniscal position, and cartilage morphologic characteristics with use of the Whole-Organ Magnetic Resonance Imaging Score system was performed by two musculoskeletal radiologists. Cross-sectional associations of severity of meniscal tears, knee malalignment, tibiofemoral cartilage damage, knee effusion, and body mass index with meniscal extrusion were assessed by using logistic regression, with multiadjustments when testing each predictor.
A total of 1527 subjects (2131 knees; 2116 medial and 2106 lateral menisci) were included. Medially, meniscal tears, varus malalignment, and cartilage damage were associated with meniscal extrusion, with odds ratios (ORs) of 6.3 (95% confidence interval [CI]: 5.0, 8.0), 1.3 (95% CI: 1.1, 1.7), and 1.8 (95% CI: 1.4, 2.2), respectively. Laterally, meniscal tears, valgus malalignment, and cartilage damage were associated with meniscal extrusion, with ORs of 10.3 (95% CI: 7.1, 14.9), 2.2 (95% CI: 1.5, 3.2), and 2.0 (95% CI: 1.3, 2.9), respectively.
Meniscal tears are not the only factors associated with meniscal extrusion; other factors include knee malalignment and cartilage damage. Meniscal extrusion is probably an effect of the complex interactions among joint tissues and mechanical stresses involved in the OA process.
Details
- Title: Subtitle
- Factors associated with meniscal extrusion in knees with or at risk for osteoarthritis: the Multicenter Osteoarthritis study
- Creators
- Michel D Crema - Department of Radiology, Boston University School of Medicine, Boston, MA 02118, USA. micrema@bu.eduFrank W RoemerDavid T FelsonMartin EnglundKe WangMohamed JarrayaMichael C NevittMonica D MarraJames C TornerCora E LewisAli Guermazi
- Resource Type
- Journal article
- Publication Details
- Radiology, Vol.264(2), pp.494-503
- DOI
- 10.1148/radiol.12110986
- PMID
- 22653191
- PMCID
- PMC3401352
- NLM abbreviation
- Radiology
- ISSN
- 1527-1315
- eISSN
- 1527-1315
- Publisher
- United States
- Grant note
- U01 AG018947 / NIA NIH HHS U01 AG018832 / NIA NIH HHS P60 AR047785 / NIAMS NIH HHS U01 AG019069 / NIA NIH HHS U01 AG018820 / NIA NIH HHS
- Language
- English
- Date published
- 08/2012
- Academic Unit
- Epidemiology; Surgery; Injury Prevention Research Center; Neurosurgery
- Record Identifier
- 9983995122002771
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