Factors influencing mortality among young women with second primary breast carcinoma

Jonine L Bernstein; Robert Lapinski; Charles Lynch; Theodore Holford; W Douglas Thompson

doi:10.1002/cncr.10950

Back

Factors influencing mortality among young women with second primary breast carcinoma

Journal article

Open access

Peer reviewed

Factors influencing mortality among young women with second primary breast carcinoma

Jonine L Bernstein, Robert Lapinski, Charles Lynch, Theodore Holford and W Douglas Thompson

Cancer, Vol.95(10), pp.2051-2058

11/15/2002

DOI: 10.1002/cncr.10950

PMID: 12412157

Files and links (1)

url

https://doi.org/10.1002/cncr.10950View

Published (Version of record) Open Access

Abstract

Tumor characteristics are strong predictors of survival among women with breast carcinoma, yet the variability in prognosis among women presenting with similar stages suggests other factors may also play an important role. We examine the prognostic significance of etiologic risk factors for breast carcinoma to determine whether factors that influence the development of breast carcinoma also affect the course of the disease among a prospective cohort of young women with bilateral breast carcinoma. The 369 U.S. women included in this study were from the Cancer and Steroid Hormone Study who were diagnosed with an invasive first primary breast carcinoma between 1980 and 1982 and a second primary breast carcinoma before 1999. Cox proportional hazards models were used to evaluate factors known and suspected to be associated with breast carcinoma and with survival, based on reporting at the time of the first primary. One hundred sixty women died during the 16-18-year follow-up period. The adjusted 1, 5, 10, and 15-year survival rates following diagnosis of second primary breast carcinoma were 94%, 70%, 55%, and 49%, respectively. Survival rates werepoorest among the youngest women, those diagnosed with a second primary within 5 years of their first, poor African American women, women with either primary diagnosed at a later stage, those with less than 12 years of school, single women, and those with major weight gain between age 18 and adulthood. This study provided little evidence that important etiologic factors for breast carcinoma predict mortality following diagnosis of a second primary breast carcinoma.

SEER Program

Age Factors

Carcinoma, Medullary - mortality

Follow-Up Studies

Humans

Middle Aged

Risk Factors

Carcinoma, Medullary - diagnosis

Proportional Hazards Models

Neoplasms, Second Primary - mortality

Survival Rate

Neoplasms, Second Primary - radiotherapy

Carcinoma, Ductal, Breast - mortality

Carcinoma, Ductal, Breast - diagnosis

Case-Control Studies

Neoplasms, Second Primary - diagnosis

Breast Neoplasms - radiotherapy

Carcinoma, Ductal, Breast - radiotherapy

Adult

Breast Neoplasms - mortality

Female

Breast Neoplasms - diagnosis

Carcinoma, Medullary - radiotherapy

Details

Title: Subtitle: Factors influencing mortality among young women with second primary breast carcinoma
Creators: Jonine L Bernstein - Department of Community and Preventive Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA. jonine.bernstein@mssm.edu
Robert Lapinski
Charles Lynch
Theodore Holford
W Douglas Thompson
Resource Type: Journal article
Publication Details: Cancer, Vol.95(10), pp.2051-2058
DOI: 10.1002/cncr.10950
PMID: 12412157
NLM abbreviation: Cancer
ISSN: 0008-543X
eISSN: 1097-0142
Publisher: United States
Grant note: 3-Y01-HD-8-1037 / NICHD NIH HHS CA69361 / NCI NIH HHS CA64245 / NCI NIH HHS
Language: English
Date published: 11/15/2002
Academic Unit: Epidemiology
Record Identifier: 9983995037202771

Metrics

13 Record Views

10 Times Cited - Web of Science