Journal article
Factors predicting double embryo implantation following double embryo transfer in assisted reproductive technology: implications for elective single embryo transfer
Journal of assisted reproduction and genetics, Vol.33(10), pp.1343-1353
10/01/2016
DOI: 10.1007/s10815-016-0770-9
PMCID: PMC5065549
PMID: 27416834
Abstract
The aim of this study was to identify factors associated with double embryo implantation following double embryo transfer (DET) during assisted reproductive technology (ART) procedures and to evaluate the implications of findings in selecting candidates for elective single embryo transfer (eSET).
Factors predicting double embryo implantation, defined as embryo transfers with two or more heartbeats on 6-week ultrasound following DET, were assessed using the US National ART Surveillance System data from 2000 to 2012 (n = 1,793,067 fresh, autologous transfers). Adjusted risk ratios (aRRs) were estimated after stratifying by prognosis. Favorable prognosis was defined as first-time ART with supernumerary embryo(s) cryopreserved. Average prognosis was defined as first-time ART without supernumerary embryo(s) cryopreserved, prior unsuccessful ART with supernumerary embryo(s) cryopreserved, or prior ART with previous birth(s) conceived with ART or naturally. Rates and factors associated with double embryo implantation were compared with single embryo implantation following DET among both prognosis groups.
Double embryo implantation was positively associated with blastocyst (versus cleavage) transfer in favorable (aRR = 1.58 (1.51-1.65)) and average (aRR = 1.67 (1.60-1.75)) prognosis groups and negatively associated with age > 35 years in both prognosis groups. For average prognosis patients, double embryo implantation was associated with retrieving > 10 oocytes (aRR = 1.22 (1.18-1.24)).
Regardless of prognosis, patients aged < 35 years with blastocyst-stage embryos and average prognosis patients from whom > 10 oocytes were retrieved may be good candidates for eSET. Physicians may consider using these data to counsel patients on eSET, which would reduce multiple gestations and associated complications.
Details
- Title: Subtitle
- Factors predicting double embryo implantation following double embryo transfer in assisted reproductive technology: implications for elective single embryo transfer
- Creators
- Caitlin Martin - National Center for Chronic Disease Prevention and Health PromotionJeani Chang - Centers for Disease Control and PreventionSheree Boulet - National Center for Chronic Disease Prevention and Health PromotionDenise J. Jamieson - National Center for Chronic Disease Prevention and Health PromotionDmitry Kissin - Centers for Disease Control and Prevention
- Resource Type
- Journal article
- Publication Details
- Journal of assisted reproduction and genetics, Vol.33(10), pp.1343-1353
- DOI
- 10.1007/s10815-016-0770-9
- PMID
- 27416834
- PMCID
- PMC5065549
- NLM abbreviation
- J Assist Reprod Genet
- ISSN
- 1058-0468
- eISSN
- 1573-7330
- Publisher
- Springer Nature
- Number of pages
- 11
- Grant note
- Marianne Ruby Award in Obstetrics and Gynecology from the Department of Gynecology and Obstetrics of Emory University
- Language
- English
- Date published
- 10/01/2016
- Academic Unit
- Obstetrics and Gynecology; VPMA - Administration
- Record Identifier
- 9984446550502771
Metrics
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