Journal article
Failure properties of abdominal aortic aneurysm tissue are orientation dependent
Journal of the mechanical behavior of biomedical materials, Vol.114, pp.104181-104181
02/2021
DOI: 10.1016/j.jmbbm.2020.104181
PMID: 33153925
Abstract
Biomechanical rupture risk assessment of abdominal aortic aneurysm (AAA) requires information about failure properties of aneurysmal tissue. There are large differences between reported values. Among others, studies vary in using either axially or circumferentially oriented samples. This study investigates the effect of sample orientation on failure properties.
Aneurysmal tissues from 45 patients (11 females) were harvested during open AAA repair, cut into uniaxial samples (90) and tested mechanically within 3 h. If possible, the samples were cut in both axial (49 samples) and circumferential (41 samples) directions. Wall thickness, First Piola-Kirchhoff strength Pult and ultimate tension Tult were recorded. Influence of sample orientation and other clinical parameters were investigated using non parametric tests.
Medians of Pult (values 1100 kPa for circumferential vs. 715 kPa for axial direction, p < 10−4) and Tult (17.4 N/cm in circumferential vs. 11.2 N/cm in axial direction, p < 10−4) were significantly higher in circumferential direction. For paired data, the median of difference was 411 kPa (p < 10−3) in Pult and 7.4 N/cm (p < 10−4) in Tult in favor of circumferential direction.
In this first study of anisotropy in AAA wall failure properties using paired comparisons, the strength in circumferential orientation was found to be higher than in axial orientation.
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•Failure properties of Abdominal aortic aneurysm studied.•45 patients; 90 samples in both axial and circumferential direction tested.•Data from 20 patients obtained in both directions for the first time.•Failure properties are significantly higher in circumferential direction.
Details
- Title: Subtitle
- Failure properties of abdominal aortic aneurysm tissue are orientation dependent
- Creators
- Stanislav Polzer - VSB - Technical University of OstravaVojtěch Man - Brno University of TechnologyRobert Vlachovský - Masaryk UniversityLuboš Kubíček - Masaryk UniversityJan Kracík - VSB - Technical University of OstravaRobert Staffa - Masaryk UniversityTomáš Novotný - Masaryk UniversityJiří Burša - Brno University of TechnologyM.L Raghavan - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Journal of the mechanical behavior of biomedical materials, Vol.114, pp.104181-104181
- Publisher
- Elsevier Ltd
- DOI
- 10.1016/j.jmbbm.2020.104181
- PMID
- 33153925
- ISSN
- 1751-6161
- eISSN
- 1878-0180
- Grant note
- DOI: 10.13039/501100001823, name: Ministerstvo Školství, Mládeže a Tělovýchovy; DOI: 10.13039/501100003243, name: Ministerstvo Zdravotnictví Ceské Republiky, award: 17–29701A
- Language
- English
- Date published
- 02/2021
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering
- Record Identifier
- 9984197012702771
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