Failure to demonstrate parent-of-origin effect in transmission of bipolar II disorder

Tadafumi Kato; George Winokur; William Coryell; John Rice; Jean Endicott; Martin B Keller; Hagop S Akiskal

doi:10.1016/S0165-0327(97)00102-X

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Failure to demonstrate parent-of-origin effect in transmission of bipolar II disorder

Journal article

Open access

Peer reviewed

Failure to demonstrate parent-of-origin effect in transmission of bipolar II disorder

Tadafumi Kato, George Winokur, William Coryell, John Rice, Jean Endicott, Martin B Keller and Hagop S Akiskal

Journal of affective disorders, Vol.50(2), pp.135-141

1998

DOI: 10.1016/S0165-0327(97)00102-X

PMID: 9858073

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https://doi.org/10.1016/S0165-0327(97)00102-XView

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Abstract

Background: Parent-of-origin effect (POE) is suggested in transmission of bipolar disorder. Bipolar II disorder (BPII) should be considered separately. Methods: The gender difference of transmitting parents, prevalence rate in children, and age at onset of patients in relation to the sex of the transmitting parent, were examined in 220 BPII patients. Results: No evidence suggesting involvement of POE was found. Conclusion: POE is not involved in transmission of BPII. Limitation: Number of subjects is not sufficient. Rate of interviewed subjects differs between mothers and fathers. Clinical relevance: Female BPII patients do not transmit the disease more often than male patients.

Bipolar disorder

Genetics

Depression

Family study

Maternal inheritance

Genomic imprinting

Details

Title: Subtitle: Failure to demonstrate parent-of-origin effect in transmission of bipolar II disorder
Creators: Tadafumi Kato - Department of Psychiatry, University of Iowa College of Medicine, Iowa City, IA 52242-1000, USA
George Winokur - Department of Psychiatry, University of Iowa College of Medicine, Iowa City, IA 52242-1000, USA
William Coryell - Department of Psychiatry, University of Iowa College of Medicine, Iowa City, IA 52242-1000, USA
John Rice - Department of Psychiatry, Washington University, St. Louis, MO 63110, USA
Jean Endicott - New York Psychiatric Institute, New York, NY, 10032 USA
Martin B Keller - Butler Hospital, Brown University, Providence, RI 02906, USA
Hagop S Akiskal - University of California at San Diego, San Diego, CA 91261, USA
Resource Type: Journal article
Publication Details: Journal of affective disorders, Vol.50(2), pp.135-141
DOI: 10.1016/S0165-0327(97)00102-X
PMID: 9858073
NLM abbreviation: J Affect Disord
ISSN: 0165-0327
eISSN: 1573-2517
Publisher: Elsevier B.V
Language: English
Date published: 1998
Academic Unit: Psychiatry
Record Identifier: 9984003421802771

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