Journal article
Familial Intracranial Aneurysms: Is Anatomic Vulnerability Heritable?
Stroke (1970), Vol.44(1), pp.38-42
2013
DOI: 10.1161/STROKEAHA.112.667261
PMID: 23204049
Abstract
Background and Purpose— Previous studies have suggested that family members with intracranial aneurysms (IAs) often harbor IAs in similar anatomic locations. IA location is important because of its association with rupture. We tested the hypothesis that anatomic susceptibility to IA location exists using a family-based IA study. Methods— We identified all affected probands and first-degree relatives (FDRs) with a definite or probable phenotype in each family. We stratified each IA of the probands by major arterial territory and calculated each family’s proband-FDR territory concordance and overall contribution to the concordance analysis. We then matched each family unit to an unrelated family unit selected randomly with replacement and performed 1001 simulations. The median concordance proportions, odds ratios (ORs), and P values from the 1001 logistic regression analyses were used to represent the final results of the analysis. Results— There were 323 family units available for analysis, including 323 probands and 448 FDRs, with a total of 1176 IAs. IA territorial concordance was higher in the internal carotid artery (55.4% versus 45.6%; OR, 1.54 [1.04–2.27]; P=0.032), middle cerebral artery (45.8% versus 30.5%; OR, 1.99 [1.22–3.22]; P=0.006), and vertebrobasilar system (26.6% versus 11.3%; OR, 2.90 [1.05–8.24], P=0.04) distributions in the true family compared with the comparison family. Concordance was also higher when any location was considered (53.0% versus 40.7%; OR, 1.82 [1.34–2.46]; P<0.001). Conclusions— In a highly enriched sample with familial predisposition to IA development, we found that IA territorial concordance was higher when probands were compared with their own affected FDRs than with comparison FDRs, which suggests that anatomic vulnerability to IA formation exists. Future studies of IA genetics should consider stratifying cases by IA location.
Details
- Title: Subtitle
- Familial Intracranial Aneurysms: Is Anatomic Vulnerability Heritable?
- Creators
- Jason MACKEY - Department of Neurology, Indiana University, Indianapolis, IN, United StatesRobert D BROWN - Department of Neurology, Mayo Clinic, Rochester, MN, United StatesCharles J MOOMAW - Department of Neurology, University of Cincinnati, Cincinnati, OH, United StatesRichard HORNUNG - Department of Emergency Medicine, University of Cincinnati, Cincinnati, OH, United StatesLaura SAUERBECK - Department of Neurology, University of Cincinnati, Cincinnati, OH, United StatesDaniel WOO - Department of Neurology, University of Cincinnati, Cincinnati, OH, United StatesTatiana FOROUD - Department of Neurology, Mayo Clinic, Rochester, MN, United StatesDheeraj GANDHI - Department of Radiology, University of Maryland, Baltimore, MD, United StatesDawn KLEINDORFER - Department of Neurology, University of Cincinnati, Cincinnati, OH, United StatesMatthew L FLAHERTY - Department of Neurology, University of Cincinnati, Cincinnati, OH, United StatesIrene MEISSNER - Department of Neurology, Indiana University, Indianapolis, IN, United StatesCraig ANDERSON - The George Institute for International Health, University of Sydney, Sydney, AustraliaGuy ROULEAU - Notre Dame Hospital, University of Montreal, Montreal, CanadaE. Sander Connolly - Department of Neurosurgery, Columbia University, New York, NY, United StatesRanjan DEKA - Department of Environmental Health, University of Cincinnati, Cincinnati, OH, United StatesDaniel L KOLLER - Department of Medical and Molecular Genetics, Indiana University, Indianapolis, IN, United StatesTodd ABRUZZO - Department of Radiology, University of Cincinnati, Cincinnati, OH, United StatesJohn HUSTON - Department of Radiology, Mayo Clinic, Rochester, MN, United StatesJoseph P BRODERICK - Department of Neurology, University of Cincinnati, Cincinnati, OH, United StatesFamilial Intracranial Aneurysm (FIA) Study Investigators
- Contributors
- Colin P Derdeyn (Contributor) - University of Iowa, Radiology
- Resource Type
- Journal article
- Publication Details
- Stroke (1970), Vol.44(1), pp.38-42
- Publisher
- Lippincott Williams & Wilkins; Hagerstown, MD
- DOI
- 10.1161/STROKEAHA.112.667261
- PMID
- 23204049
- ISSN
- 0039-2499
- eISSN
- 1524-4628
- Language
- English
- Date published
- 2013
- Academic Unit
- Neurology; Radiology; Iowa Neuroscience Institute; Neurosurgery
- Record Identifier
- 9984020613202771
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