Journal article
Familial Mediterranean fever in Arabs
The Lancet (British edition), Vol.367(9515), pp.1016-1024
2006
DOI: 10.1016/S0140-6736(06)68430-4
PMID: 16564365
Abstract
Autoinflammatory diseases are a group of disorders characterised by seemingly unprovoked inflammation in the absence of high-titre autoantibodies or antigen-specific T cells, and include the hereditary periodic fever syndromes. Familial Mediterranean fever (FMF) is an archetypal autoinflammatory disorder, which is autosomal recessive and has a high prevalence in non-Ashkenazi Jews, Armenians, Turks, and Arabs. The classic clinical picture is recurrent acute short-lived febrile and painful attacks with variable periods of remission. In a subset of patients, the disorder is complicated by amyloidosis that leads to renal failure. The gene responsible for FMF—
MEFV—has been identified and its role in inflammation is being assessed. There seems to be a distinctive clinical picture in Arab patients with FMF, and the range and distribution of
MEFV mutations is different from that noted in other affected ethnic groups. Here, we discuss the clinical and molecular aspects of FMF in Arabs.
Details
- Title: Subtitle
- Familial Mediterranean fever in Arabs
- Creators
- Hatem El-Shanti - University of IowaHasan Abdel Majeed - University of JordanMohammed El-Khateeb - University of Jordan
- Resource Type
- Journal article
- Publication Details
- The Lancet (British edition), Vol.367(9515), pp.1016-1024
- Publisher
- Elsevier Ltd
- DOI
- 10.1016/S0140-6736(06)68430-4
- PMID
- 16564365
- ISSN
- 0140-6736
- eISSN
- 1474-547X
- Language
- English
- Date published
- 2006
- Academic Unit
- Stead Family Department of Pediatrics; Medical Genetics and Genomics
- Record Identifier
- 9984354051302771
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