Journal article
Familial Mediterranean fever in children: the expanded clinical profile
QJM : monthly journal of the Association of Physicians, Vol.92(6), pp.309-318
06/1999
DOI: 10.1093/qjmed/92.6.309
PMID: 10616706
Abstract
The clinical picture of familial Mediterranean fever (FMF) has been appreciably expanded in the last 10 years. Over 8 years, we studied the expanded clinical profile of FMF in 476 children. Of these, 81% had abdominal pain, 41% chest pain, 42% arthritis, 12% severe myalgia, 12% skin manifestations, 4% scrotal swelling, 3% recurrent episodic fever, and one child (0.2%) developed recurrent hyperbilirubinaemia. Two (0.4%) children developed renal complications which were reversed by colchicine; however of 19 probands, 36 family members suffered from chronic renal failure. Our study indicates a familial predisposition to nephropathy in certain families with FMF. This study is the first to report the expanded clinical profile of FMF in a large group of Arab children, giving an opportunity to compare the findings with those in children with FMF in other ethnic groups, and to help in the study of genotype-phenotype correlation.
Details
- Title: Subtitle
- Familial Mediterranean fever in children: the expanded clinical profile
- Creators
- H.A. Majeed - University of JordanM. Rawashdeh - Jordan University of Science and TechnologyH. El-Shanti - Jordan University of Science and TechnologyH. QubainN. Khuri-BulosH.M. Shahin
- Resource Type
- Journal article
- Publication Details
- QJM : monthly journal of the Association of Physicians, Vol.92(6), pp.309-318
- DOI
- 10.1093/qjmed/92.6.309
- PMID
- 10616706
- NLM abbreviation
- QJM
- ISSN
- 1460-2725
- eISSN
- 1460-2393
- Publisher
- Oxford University Press
- Language
- English
- Date published
- 06/1999
- Academic Unit
- Stead Family Department of Pediatrics; Medical Genetics and Genomics
- Record Identifier
- 9984353929802771
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