Journal article
Familial adenomatous polyposis
Seminars in surgical oncology, Vol.18(4), pp.314-323
06/2000
DOI: 10.1002/(SICI)1098-2388(200006)18:4<314::AID-SSU6>3.0.CO;2-9
PMID: 10805953
Abstract
Familial adenomatous polyposis (FAP) is a dominantly inherited familial cancer syndrome characterized by an increased predisposition to colorectal cancer and other benign and malignant extracolonic lesions. FAP has been linked to germline mutations of the adenomatous polyposis coli (APC) gene that encodes a protein with 2,843 amino acids that has important functions in the regulation of cell growth. A genotype-phenotype correlation has also been observed between mutations in the APC gene and polyp phenotype. We review the clinical and genetic features of this disorder and provide information on the diagnostic approaches and treatment options available for this disease. (C) 2000 Wiley-Liss, Inc.
Details
- Title: Subtitle
- Familial adenomatous polyposis
- Creators
- Geeta Lal - University of TorontoSteven Gallinger - Mount Sinai Hospital
- Resource Type
- Journal article
- Publication Details
- Seminars in surgical oncology, Vol.18(4), pp.314-323
- Publisher
- John Wiley & Sons, Inc
- DOI
- 10.1002/(SICI)1098-2388(200006)18:4<314::AID-SSU6>3.0.CO;2-9
- PMID
- 10805953
- ISSN
- 8756-0437
- eISSN
- 1098-2388
- Number of pages
- 9
- Language
- English
- Date published
- 06/2000
- Academic Unit
- Stead Family Department of Pediatrics; Surgery
- Record Identifier
- 9984322940102771
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